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Baseline Body Composition in Prepubertal Short Stature Children with Severe and Moderate Growth Hormone Deficiency
Joint Authors
Matusik, Pawel
Malecka-Tendera, Ewa
Klesiewicz, Marta
Klos, Karolina
Stasiulewicz, Martyna
Barylak, Aleksandra
Nazarkiewicz, Patrycja
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To compare body composition parameters in short children with severe versus moderate and no growth hormone deficiency (GHD).
Design and Method.
61 children (40 boys) were studied.
Height SDS, BMI Z-score, waist/height ratio (W/HtR), and body composition parameters (BIA) as fat tissue (FAT%), fat-free mass (FFM%), predicted muscle mass (PMM%), and total body water (TBW%) were evaluated.
GH secretion in the overnight profile and two stimulation tests and insulin-like growth factor 1 (IGF-1) level were measured.
Results.
Overall, in 16 (26%) moderate (7.0 > peak GH < 10 ng/mL) and in 11 (18%) severe (GH ≤ 7.0 ng/mL) GHD was diagnosed.
In children with sGHD BMI Z-score, W/HtR and FAT% were significantly higher, while FFM%, PMM%, and TBW% were significantly lower versus mGHD and versus noGHD subgroups.
No significant differences between mGHD and noGHD were found.
There were no differences in height SDS and IGF-1 SDS between evaluated subgroups.
Night GH peak level correlated significantly with FAT%, FFM%, PMM%, and TBW%, (p<0.05) in the entire group.
Conclusions.
Only sGHD is associated with significant impairment of body composition.
Body composition analysis may be a useful tool in distinguishing between its severe and moderate form of GHD.
American Psychological Association (APA)
Matusik, Pawel& Klesiewicz, Marta& Klos, Karolina& Stasiulewicz, Martyna& Barylak, Aleksandra& Nazarkiewicz, Patrycja…[et al.]. 2016. Baseline Body Composition in Prepubertal Short Stature Children with Severe and Moderate Growth Hormone Deficiency. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105885
Modern Language Association (MLA)
Matusik, Pawel…[et al.]. Baseline Body Composition in Prepubertal Short Stature Children with Severe and Moderate Growth Hormone Deficiency. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1105885
American Medical Association (AMA)
Matusik, Pawel& Klesiewicz, Marta& Klos, Karolina& Stasiulewicz, Martyna& Barylak, Aleksandra& Nazarkiewicz, Patrycja…[et al.]. Baseline Body Composition in Prepubertal Short Stature Children with Severe and Moderate Growth Hormone Deficiency. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1105885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105885