Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study
Joint Authors
Tirabassi, Giacomo
Maggi, Mario
delli Muti, Nicola
Corona, Giovanni
Balercia, Giancarlo
Falzetti, Sara
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
No study has assessed the possible involvement of GGC androgen receptor (AR) polymorphism in sexual function.
Our aim is to evaluate the association between CAG and GGC AR polymorphisms in this function.
Methods.
We retrospectively examined eighty-five outpatients.
Clinical, biochemical, and genetic parameters were considered.
Sexual assessment was performed using the International Index of Erectile Function (IIEF) which evaluates erectile function (EF), orgasmic function (OF), sexual desire (SD), intercourse satisfaction (IS), and overall satisfaction (OS).
Results.
In the whole sample, CAG repeats were inversely correlated with EF, OF, and total IIEF-15 score, whereas GGC tracts did not show any significant correlation with sexual function.
CAG relationship with IIEF items retained significance only in the eugonadal but not in the hypogonadal cohort.
On the other hand, GGC tracts were not found to be significantly correlated with IIEF variables in either eugonadal or hypogonadal subjects.
In eugonadal subjects, logistic regression pointed out that a higher number of CAG triplets were associated with lower values of EF, OF, SD, OS, and total IIEF independently from other confounders.
Conclusions.
GGC polymorphism seems not to exert any influence on sexual function, whereas CAG polymorphism appears to affect sexual parameters only in eugonadal subjects.
American Psychological Association (APA)
Tirabassi, Giacomo& Corona, Giovanni& Falzetti, Sara& delli Muti, Nicola& Maggi, Mario& Balercia, Giancarlo. 2016. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105902
Modern Language Association (MLA)
Tirabassi, Giacomo…[et al.]. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105902
American Medical Association (AMA)
Tirabassi, Giacomo& Corona, Giovanni& Falzetti, Sara& delli Muti, Nicola& Maggi, Mario& Balercia, Giancarlo. Influence of Androgen Receptor Gene CAG and GGC Polymorphisms on Male Sexual Function: A Cross-Sectional Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105902
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105902