Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus
Joint Authors
Liu, Wendong
Wang, Limin
Liu, Minghua
Li, Guimei
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
In pediatric central diabetes insipidus (CDI), etiology diagnosis and pituitary function monitoring are usually delayed.
This study aimed to illustrate the importance of regular follow-up and pituitary function monitoring in pediatric CDI.
Methods.
The clinical, hormonal, and neuroradiological characteristics of children with CDI at diagnosis and during 1.5–2-year follow-up were collected and analyzed.
Results.
The study included 43 CDI patients.
The mean interval between initial manifestation and diagnosis was 22.29 ± 3.67 months (range: 2–108 months).
The most common complaint was polyuria/polydipsia.
Causes included Langerhans cell histiocytosis, germinoma, and craniopharyngioma in 2, 5, and 4 patients; the remaining were idiopathic.
No significant changes were found during the 1.5–2 years after CDI diagnosis.
Twenty-three of the 43 cases (53.5%) had ≥1 anterior pituitary hormone deficiency.
Isolated growth hormone deficiency was the most frequent abnormality (37.5%) and was not associated with pituitary stalk diameter.
Multiple pituitary hormone deficiencies were found in 8 cases with pituitary stalk diameter > 4.5 mm.
Conclusion.
Diagnosis of CDI is usually delayed.
CDI with a pituitary stalk diameter > 4.5 mm carries a higher risk of multiple pituitary hormone deficiencies.
Long-term MRI and pituitary function follow-ups are necessary for children with idiopathic CDI.
American Psychological Association (APA)
Liu, Wendong& Wang, Limin& Liu, Minghua& Li, Guimei. 2016. Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105948
Modern Language Association (MLA)
Liu, Wendong…[et al.]. Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1105948
American Medical Association (AMA)
Liu, Wendong& Wang, Limin& Liu, Minghua& Li, Guimei. Pituitary Morphology and Function in 43 Children with Central Diabetes Insipidus. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1105948
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105948