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Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia
Joint Authors
Scioscia, Marco
Kunjara, Sirilaksana
McLean, Patricia
Rademacher, Laurens
Rademacher, Thomas W.
Fascilla, Fabiana
Bettocchi, Stefano
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Immunological alterations, endothelial dysfunction, and insulin resistance characterize preeclampsia.
Endothelial cells hold the key role in the pathogenesis of this disease.
The signaling pathways mediating these biological abnormalities converge on PKB/Akt, an intracellular kinase regulating cell survival, proliferation, and metabolism.
Inositol second messengers are involved in metabolic and cell signaling pathways and are highly expressed during preeclampsia.
Intracellular action of these molecules is deeply affected by zinc, manganese, and calcium.
To evaluate the pathophysiological significance, we present the response of the intracellular pathways of inositol phosphoglycans involved in cellular metabolism and propose a link with the disease.
American Psychological Association (APA)
Kunjara, Sirilaksana& McLean, Patricia& Rademacher, Laurens& Rademacher, Thomas W.& Fascilla, Fabiana& Bettocchi, Stefano…[et al.]. 2016. Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105981
Modern Language Association (MLA)
Kunjara, Sirilaksana…[et al.]. Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia. International Journal of Endocrinology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1105981
American Medical Association (AMA)
Kunjara, Sirilaksana& McLean, Patricia& Rademacher, Laurens& Rademacher, Thomas W.& Fascilla, Fabiana& Bettocchi, Stefano…[et al.]. Putative Key Role of Inositol Messengers in Endothelial Cells in Preeclampsia. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1105981
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1105981