The Association of Peroxisome Proliferator-Activated Receptor δ and Additional Gene-Gene Interaction with C-Reactive Protein in Chinese Population

Abstract EN

Aims.

To examine the association between 4 single nucleotide polymorphisms (SNPs) of peroxisome proliferator-activated receptors δ (PPARδ) polymorphisms and C-reactive protein (CRP) level and additional gene-gene interaction.

Methods.

Line regression analysis was performed to verify polymorphism association between SNP and CRP levels.

Generalized multifactor dimensionality reduction (GMDR) was employed to analyze the interaction.

Results.

A total of 1028 subjects (538 men, 490 women) were selected.

The carriers of the C allele (TC or CC) of rs2016520 were associated with a significant decreased level of CRP, regression coefficients was −0.338, and standard error was 0.104 ( p = 0.001 ).

The carriers of the G allele (CG or GG) of rs9794 were also significantly associated with decreased level of CRP, regression coefficients was −0.219, and standard error was 0.114 ( p = 0.012 ).

We also found a potential gene-gene interaction between rs2016520 and rs9794.

Subjects with rs2016520-TC or CC, rs9794-CG or GG genotypes have lowest CRP level, difference (95% CI) = −0.50 (−0.69 to −0.21) ( p < 0.001 ), compared to subjects with rs2016520-TT and rs9794-CC genotypes.

Conclusions.

rs2016520 and rs9794 minor allele of PPARδ and combined effect between the two SNP were associated with decreased CRP level.