The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study
Joint Authors
Doh, Emmanuella
Mbanya, Armand
Dohbit, Sama
Tchana-Sinou, Mycilline
Foumane, Pascal
Donfack, Olivier Trésor
Mbanya, Jean Claude
Sobngwi, Eugene
Kemfang Ngowa, J. D.
Doh, A. S.
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-08
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objectives.
We aimed to assess the variation of insulin sensitivity in relation to obesity in women living with PCOS in a sub-Sahara African setting.
Methods.
We studied body composition, insulin sensitivity, and resting energy expenditure in 14 PCOS patients (6 obese and 8 nonobese) compared to 10 matched nonobese non-PCOS subjects.
Insulin sensitivity was assessed using the gold standard 80 mU/m2/min euglycemic-hyperinsulinemic clamp and resting energy expenditure was measured by indirect calorimetry.
Results.
Insulin sensitivity adjusted to lean mass was lowest in obese PCOS subjects and highest in healthy subjects (11.2 [ 10.1–12.4 ] versus 12.9 [ 12.1–13.8 ] versus 16.6 [ 13.8–17.9 ] , p = 0.012 ); there was a tendency for resting energy expenditure adjusted for total body mass to decrease across the groups highest in obese PCOS subjects (1411 [ 1368–1613 ] versus 1274 [ 1174–1355 ] versus 1239 [ 1195–1454 ] , p = 0.306 ).
Conclusion.
In this sub-Saharan population, insulin resistance is associated with PCOS per se but is further aggravated by obesity.
Obesity did not seem to be explained by low resting energy expenditure suggesting that dietary intake may be a determinant of the obesity in this context.
American Psychological Association (APA)
Doh, Emmanuella& Mbanya, Armand& Kemfang Ngowa, J. D.& Dohbit, Sama& Tchana-Sinou, Mycilline& Foumane, Pascal…[et al.]. 2016. The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106047
Modern Language Association (MLA)
Doh, Emmanuella…[et al.]. The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study. International Journal of Endocrinology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106047
American Medical Association (AMA)
Doh, Emmanuella& Mbanya, Armand& Kemfang Ngowa, J. D.& Dohbit, Sama& Tchana-Sinou, Mycilline& Foumane, Pascal…[et al.]. The Relationship between Adiposity and Insulin Sensitivity in African Women Living with the Polycystic Ovarian Syndrome: A Clamp Study. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106047
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106047