Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer
Joint Authors
Chao, Tzu-Chieh
Tsang, Ngan-Ming
Liou, Miaw-Jene
Hsueh, Chuen
Lin, Jen-Der
Source
International Journal of Endocrinology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The aims of this study were to analyze the clinical characteristics of SPM in patients with well-differentiated thyroid cancer and to determine the long-term prognosis in patients with double malignancies.
Materials and Methods.
We retrospectively analyzed 2,864 patients with well-differentiated thyroid cancer and a mean age of 44.0±14.4 years.
Of these, 200 (7.0%) were diagnosed with SPM, 115 of which were diagnosed with metachronous SPM.
Results.
Of 2,864 patients, 163 (5.7%) patients died of thyroid cancer and 301 (10.5%) died of any cause by the end of the follow-up period.
Multivariate analysis identified age, SPM, external radiotherapy, TNM stage, and postoperative serum Tg level to be factors independently associated with decreased survival.
Of 200 patients with SPM, 74 (37.0%) died.
In comparison to the anachronous and synchronous groups, the metachronous SPM group had a higher mean age; more advanced tumor, node, and metastasis stage; lower remission rate; higher postoperative radioactive iodide (131I) accumulated dose; a higher proportion of patients who underwent external radiotherapy; and higher thyroid cancer and total mortality rates.
Conclusions.
Patients with well-differentiated thyroid carcinoma and metachronous SPM had worse prognoses compared to patients without SPM.
American Psychological Association (APA)
Liou, Miaw-Jene& Tsang, Ngan-Ming& Hsueh, Chuen& Chao, Tzu-Chieh& Lin, Jen-Der. 2016. Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer. International Journal of Endocrinology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106054
Modern Language Association (MLA)
Liou, Miaw-Jene…[et al.]. Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer. International Journal of Endocrinology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106054
American Medical Association (AMA)
Liou, Miaw-Jene& Tsang, Ngan-Ming& Hsueh, Chuen& Chao, Tzu-Chieh& Lin, Jen-Der. Therapeutic Outcome of Second Primary Malignancies in Patients with Well-Differentiated Thyroid Cancer. International Journal of Endocrinology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106054
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106054