Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning—Experience from India
Joint Authors
Bansal, Nalini
Vij, Vivek
Rastogi, Mukul
Source
International Journal of Hepatology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
The goal of this study was to determine the etiopathological association of various hepatic nodules identified during gross examination of liver explants specimen and the grossing aspects of these abnormal nodules especially those smaller than 1 cm in diameter.
Our aim was to analyze whether there is any association of macroregenerative and dysplastic nodule with hepatocellular carcinoma.
Materials and Methods.
Fifty consecutive liver explants specimens were analyzed for the presence of any abnormal nodule (abnormal nodule defined as any nodule different in color, texture, and appearance from adjacent liver tissue).
Results.
Of the total 40 abnormal nodules identified in 50 liver explant specimens, there were 12 (30%) HCC [including 5 small HCC (41% of total HCC) and 1 steatohepatitic HCC (8% of total HCC)], 11 (27%) MRNs, 8 (20%) dysplastic nodules, and 9 (22%) necrotic nodules.
Most cases (72%) of MRN are seen in hepatitis C virus related cirrhosis with only 2 cases having associated HCC.
Most cases of HCC were seen in cases of HBV associated cirrhosis (60%).
The association of MRN was not found to be significantly associated with HCC with a p value of 1.0.
Dysplastic nodules were found to be significantly associated with HCC with a p value of 0.02.
Conclusion.
In hepatic carcinogenesis, the role of MRN does not appear to be significant.
However, the presence of dysplastic nodules is significantly associated with HCC.
The study identified another variant of cirrhotic nodules herein called necrotic nodules that are mostly tan greenish in color and <0.5 cm in diameter.
No dysplastic changes were identified in any of these nodules disqualifying the need of sectioning in such nodules.
American Psychological Association (APA)
Bansal, Nalini& Vij, Vivek& Rastogi, Mukul. 2016. Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning—Experience from India. International Journal of Hepatology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106215
Modern Language Association (MLA)
Bansal, Nalini…[et al.]. Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning—Experience from India. International Journal of Hepatology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1106215
American Medical Association (AMA)
Bansal, Nalini& Vij, Vivek& Rastogi, Mukul. Different Nodules Identified during Liver Explant Gross Examination: Relevance and Need for Sectioning—Experience from India. International Journal of Hepatology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1106215
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106215