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Spectrum and the In Vitro Antifungal Susceptibility Pattern of Yeast Isolates in Ethiopian HIV Patients with Oropharyngeal Candidiasis
Joint Authors
Bitew, Adane
Moges, Birhan
Shewaamare, Aster
Source
International Journal of Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
In Ethiopia, little is known regarding the distribution and the in vitro antifungal susceptibility profile of yeasts.
Objective.
This study was undertaken to determine the spectrum and the in vitro antifungal susceptibility pattern of yeasts isolated from HIV infected patients with OPC.
Method.
Oral pharyngeal swabs taken from oral lesions of study subjects were inoculated onto Sabouraud Dextrose Agar.
Yeasts were identified by employing conventional test procedures and the susceptibility of yeasts to antifungal agents was evaluated by disk diffusion assay method.
Result.
One hundred and fifty-five yeast isolates were recovered of which 91 isolates were from patients that were not under HAART and 64 were from patients that were under HAART.
C.
albicans was the most frequently isolated species followed by C.
glabrata, C.
tropicalis, C.
krusei, C.
kefyr, Cryptococcus laurentii, and Rhodotorula species.
Irrespective of yeasts isolated and identified, 5.8%, 5.8%, 12.3%, 8.4%, 0.6%, and 1.3% of the isolates were resistant to amphotericin B, clotrimazole, fluconazole, ketoconazole, miconazole, and nystatin, respectively.
Conclusion.
Yeast colonization rate of 69.2% and 31% resistance to six antifungal agents was documented.
These highlight the need for nationwide study on the epidemiology of OPC and resistance to antifungal drugs.
American Psychological Association (APA)
Moges, Birhan& Bitew, Adane& Shewaamare, Aster. 2016. Spectrum and the In Vitro Antifungal Susceptibility Pattern of Yeast Isolates in Ethiopian HIV Patients with Oropharyngeal Candidiasis. International Journal of Microbiology،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106259
Modern Language Association (MLA)
Moges, Birhan…[et al.]. Spectrum and the In Vitro Antifungal Susceptibility Pattern of Yeast Isolates in Ethiopian HIV Patients with Oropharyngeal Candidiasis. International Journal of Microbiology No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1106259
American Medical Association (AMA)
Moges, Birhan& Bitew, Adane& Shewaamare, Aster. Spectrum and the In Vitro Antifungal Susceptibility Pattern of Yeast Isolates in Ethiopian HIV Patients with Oropharyngeal Candidiasis. International Journal of Microbiology. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1106259
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106259