Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana
Joint Authors
Owusu, Enid
Newman, Mercy Jemima
Kotey, Nana Konama
Akumwena, Amos
Bannerman, Elizabeth
Source
International Journal of Microbiology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-14
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Drug resistance is a major challenge in antibiotic chemotherapy.
Assessing resistance profiles of pathogens constitutes an essential surveillance tool in the epidemiology and control of infectious diseases, including Buruli ulcer (BU) disease.
With the successful definitive management of BU using rifampicin and streptomycin, little attention had been paid to monitoring emergence of resistant Mycobacterium ulcerans (M.
ulcerans) isolates in endemic communities.
This study investigated the susceptibility profiles of M.
ulcerans isolates from two BU endemic areas in Ghana to streptomycin and rifampicin.
Methods.
The antibiotic susceptibility of seventy (70) M.
ulcerans isolates to rifampicin and streptomycin was determined simultaneously at critical concentrations of 40 µg/mL and 4 µg/mL, respectively, by the Canetti proportion method.
Results.
Resistance to rifampicin was observed for 12 (17.1%) M.
ulcerans isolates tested, whilst 2 (2.9%) showed resistance to streptomycin.
None of the isolates tested showed dual resistance to both rifampicin and streptomycin.
Conclusion.
Outcomes from this study may not be reflective of all BU endemic communities; it, however, provides information on the resistance status of the isolates, which is useful for monitoring of M.
ulcerans, as well as BU disease surveillance and control.
American Psychological Association (APA)
Owusu, Enid& Newman, Mercy Jemima& Kotey, Nana Konama& Akumwena, Amos& Bannerman, Elizabeth. 2016. Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana. International Journal of Microbiology،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106286
Modern Language Association (MLA)
Owusu, Enid…[et al.]. Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana. International Journal of Microbiology No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1106286
American Medical Association (AMA)
Owusu, Enid& Newman, Mercy Jemima& Kotey, Nana Konama& Akumwena, Amos& Bannerman, Elizabeth. Susceptibility Profiles of Mycobacterium ulcerans Isolates to Streptomycin and Rifampicin in Two Districts of the Eastern Region of Ghana. International Journal of Microbiology. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1106286
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106286