![](/images/graphics-bg.png)
Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome
Joint Authors
Jalanko, Hannu
Suvanto, Maija
Jahnukainen, Timo
Kestilä, Marjo
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Polymorphic variants in several molecules involved in the glomerular function and drug metabolism have been implicated in the pathophysiology of pediatric idiopathic nephrotic syndrome (INS), but the results remain inconsistent.
We analyzed the association of eleven allelic variants in eight genes (angiopoietin-like 4 (ANGPTL4), glypican 5 (GPC5), interleukin-13 (IL-13), macrophage migration inhibitory factor (MIF), neural nitric oxide synthetase (nNOS), multidrug resistance-1 (MDR1), glucocorticoid-induced transcript-1 (GLCCI1), and nuclear receptor subfamily-3 (NR3C1)) in 100 INS patients followed up till adulthood.
We genotyped variants using PCR and direct sequencing and evaluated estimated haplotypes of MDR1 variants.
The analysis revealed few differences in SNP genotype frequencies between patients and controls, or in clinical parameters among the patients.
Genotype distribution of MDR1 SNPs rs1236, rs2677, and rs3435 showed significant (p<0.05) association with different medication regimes (glucocorticoids only versus glucocorticoids plus additional immunosuppressives).
Some marginal association was detected between ANGPTL4, GPC5, GLCCI1, and NR3C1 variants and different medication regimes, number of relapses, and age of onset.
Conclusion.
While MDR1 variant genotype distribution associated with different medication regimes, the other analyzed gene variants showed only little or marginal clinical relevance in INS.
American Psychological Association (APA)
Suvanto, Maija& Jahnukainen, Timo& Kestilä, Marjo& Jalanko, Hannu. 2016. Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106336
Modern Language Association (MLA)
Suvanto, Maija…[et al.]. Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome. International Journal of Nephrology No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1106336
American Medical Association (AMA)
Suvanto, Maija& Jahnukainen, Timo& Kestilä, Marjo& Jalanko, Hannu. Single Nucleotide Polymorphisms in Pediatric Idiopathic Nephrotic Syndrome. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1106336
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106336