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Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant
Joint Authors
Oliveira, Vanessa
Souza, Livia Victorino de
Laurindo, Aline Oliveira
Huarachı, DelmaRegına Gomes
Nogueira, Paulo Cesar Koch
Feltran, Luciana de Santis
Medina-Pestana, José Osmar
Franco, Maria do Carmo
Source
International Journal of Nephrology
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-19
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Endocan is an important biomarker of inflammation and endothelial dysfunction that increases in association with several chronic diseases.
Few published data have described the role of endocan in pediatric renal transplant (RT) patients.
We evaluated the endocan concentrations in 62 children who underwent renal transplantation and assessed their relationships with the patients’ blood pressure and loss of renal function.
The endocan levels were significantly elevated in the pediatric RT patients who had hypertension and a loss of renal function.
We determined positive correlations between the endocan concentrations and the hemodynamic variables (systolic blood pressure: r=0.416; P=0.001; pulse pressure: r=0.412; P=0.003).
The endocan levels were inversely correlated with the estimated glomerular filtration rate (r=-0.388; P=0.003).
An endocan cutoff concentration of 7.0 ng/mL identified pediatric RT patients who had hypertension and a loss of renal function with 100% sensitivity and 75% specificity.
In conclusion, the endocan concentrations were significantly elevated in pediatric RT patients who had both hypertension and a loss of renal function.
The correlations between the endocan levels and the hemodynamic variables and the markers of renal function strengthen the hypothesis that it is an important marker of cardiorenal risk.
American Psychological Association (APA)
Souza, Livia Victorino de& Oliveira, Vanessa& Laurindo, Aline Oliveira& Huarachı, DelmaRegına Gomes& Nogueira, Paulo Cesar Koch& Feltran, Luciana de Santis…[et al.]. 2016. Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant. International Journal of Nephrology،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106339
Modern Language Association (MLA)
Souza, Livia Victorino de…[et al.]. Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant. International Journal of Nephrology No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1106339
American Medical Association (AMA)
Souza, Livia Victorino de& Oliveira, Vanessa& Laurindo, Aline Oliveira& Huarachı, DelmaRegına Gomes& Nogueira, Paulo Cesar Koch& Feltran, Luciana de Santis…[et al.]. Serum Endocan Levels Associated with Hypertension and Loss of Renal Function in Pediatric Patients after Two Years from Renal Transplant. International Journal of Nephrology. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1106339
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1106339