Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients
Joint Authors
Duan, Lihua
Shi, Guixiu
He, Yan
Qian, Hongyan
Huang, Yan
Su, Qun
Lin, Qingyan
Liu, Wen
Luo, Jiao
Yu, Bing
Liu, Yuan
Chen, Jie
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-07
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Interleukin-33 (IL-33), the most recently discovered member of the IL-1 superfamily, has been linked to several human pathologies including autoimmune diseases, sepsis, and allergy through its specific IL-1 receptor ST2.
However, there is little information regarding the role of IL-33 in gout.
In this study, we investigated the potential role of IL-33 in gout patients.
The serum level of IL-33 was measured by ELISA, and the clinical and laboratory parameters, serum creatinine, urea, and lipid, were extracted from medical record system.
The serum IL-33 expression was predominantly increased in gout patients compared to healthy controls, and the IL-33 levels were higher in patients without kidney injury.
Furthermore, IL-33 showed a negative correlation with biomarkers of kidney injury, such as CRE and urea.
The lipid metabolism dysfunction, tophi, and hypertension are the common reasons for kidney injury in gout.
Interestingly, inverse and positive correlation of IL-33 expression was observed in LDL and HDL, respectively.
However, there was no significant alteration in the gout patients with hypertension and tophi.
These data suggested that IL-33 might act as a protective role in kidney injury through regulating the lipid metabolism in gout.
American Psychological Association (APA)
Duan, Lihua& Huang, Yan& Su, Qun& Lin, Qingyan& Liu, Wen& Luo, Jiao…[et al.]. 2016. Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107944
Modern Language Association (MLA)
Duan, Lihua…[et al.]. Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients. Journal of Diabetes Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1107944
American Medical Association (AMA)
Duan, Lihua& Huang, Yan& Su, Qun& Lin, Qingyan& Liu, Wen& Luo, Jiao…[et al.]. Potential of IL-33 for Preventing the Kidney Injury via Regulating the Lipid Metabolism in Gout Patients. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1107944
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107944