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GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance
Joint Authors
Gülbahar, Özlem
Altınova, Eroğlu
Aktürk, Müjde
Törüner, Baloş
Yalcin, Mehmet Muhittin
Arslan, Emre
Ors Sendogan, Damla
Yetkin, Ilhan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Aims.
Growth Differentiation Factor-15 (GDF-15) has been suggested as one of the regulators of hepcidin, an important regulatory peptide for iron deposition.
Current data is conflicting about the relationship between hepcidin and disorders of glucose metabolism.
We aimed to investigate serum hepcidin and GDF-15 concentrations and their associations with each other, in nonanemic subjects with impaired glucose tolerance (IGT) in comparison with the nonanemic subjects with normal glucose tolerance (NGT).
Methods.
Thirty-seven subjects with IGT and 32 control subjects with NGT, who were age-, gender-, and body mass index- (BMI-) matched, were included in the study.
Results.
Serum GDF-15 levels were significantly higher in IGT compared to NGT.
There were no differences in hepcidin, interleukin-6, and high sensitive C-reactive protein levels between the groups.
We found a positive correlation between GDF-15 and hepcidin levels.
There were also positive correlations between GDF-15 and age, uric acid, creatinine, and area under the curve for glucose (AUC-G).
Hepcidin was correlated positively with ferritin levels.
In the multiple regression analysis, GDF-15 concentrations were independently associated with age, uric acid, and AUC-G.
Conclusions.
Impaired glucose tolerance is associated with increased GDF-15 levels even in the absence of anemia, but the levels of hepcidin are not significantly altered in prediabetic state.
American Psychological Association (APA)
Yalcin, Mehmet Muhittin& Altınova, Eroğlu& Aktürk, Müjde& Gülbahar, Özlem& Arslan, Emre& Ors Sendogan, Damla…[et al.]. 2016. GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107949
Modern Language Association (MLA)
Yalcin, Mehmet Muhittin…[et al.]. GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance. Journal of Diabetes Research No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1107949
American Medical Association (AMA)
Yalcin, Mehmet Muhittin& Altınova, Eroğlu& Aktürk, Müjde& Gülbahar, Özlem& Arslan, Emre& Ors Sendogan, Damla…[et al.]. GDF-15 and Hepcidin Levels in Nonanemic Patients with Impaired Glucose Tolerance. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1107949
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1107949