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Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
Joint Authors
Gluhovschi, Cristina
Gluhovschi, Gheorghe
Petrica, Ligia
Velciov, Silvia
Timar, Romulus
Ionita, Ioana
Kaycsa, Adriana
Timar, Bogdan
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-16
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM).
Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis.
Towards this aim, biomarkers for detecting early DN can be used.
Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression.
New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients.
However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN.
Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury.
Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation.
Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early.
Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN.
The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN.
American Psychological Association (APA)
Gluhovschi, Cristina& Gluhovschi, Gheorghe& Petrica, Ligia& Timar, Romulus& Velciov, Silvia& Ionita, Ioana…[et al.]. 2016. Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108124
Modern Language Association (MLA)
Gluhovschi, Cristina…[et al.]. Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy. Journal of Diabetes Research No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1108124
American Medical Association (AMA)
Gluhovschi, Cristina& Gluhovschi, Gheorghe& Petrica, Ligia& Timar, Romulus& Velciov, Silvia& Ionita, Ioana…[et al.]. Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1108124
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108124