Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration
Joint Authors
Chuang, Lee-Ming
Karnchanasorn, Rudruidee
Samoa, Raynald
Chiu, Ken C.
Huang, Jean
Ou, Horng-Yih
Feng, Wei
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
To determine the effectiveness of hemoglobin A1c (HbA1c) ≥ 6.5% in diagnosing diabetes compared to fasting plasma glucose (FPG) ≥ 126 mg/dL and 2-hour plasma glucose (2hPG) ≥ 200 mg/dL in a previously undiagnosed diabetic cohort, we included 5,764 adult subjects without established diabetes for whom HbA1c, FPG, 2hPG, and BMI measurements were collected.
Compared to the FPG criterion, the sensitivity of HbA1c ≥ 6.5% was only 43.3% (106 subjects).
Compared to the 2hPG criterion, the sensitivity of HbA1c ≥ 6.5% was only 28.1% (110 subjects).
Patients who were diabetic using 2hPG criterion but had HbA1c < 6.5% were more likely to be older ( 64 ± 15 versus 60 ± 15 years old, P = 0.01 , mean ± STD), female (53.2% versus 38.2%, P = 0.008 ), leaner ( 29.7 ± 6.1 versus 33.0 ± 6.6 kg/m2, P = 0.00000 5 ), and less likely to be current smokers (18.1% versus 29.1%, P = 0.02 ) as compared to those with HbA1c ≥ 6.5%.
The diagnostic agreement in the clinical setting revealed the current HbA1c ≥ 6.5% is less likely to detect diabetes than those defined by FPG and 2hPG.
HbA1c ≥ 6.5% detects less than 50% of diabetic patients defined by FPG and less than 30% of diabetic patients defined by 2hPG.
When the diagnosis of diabetes is in doubt by HbA1c, FPG and/or 2hPG should be obtained.
American Psychological Association (APA)
Karnchanasorn, Rudruidee& Huang, Jean& Ou, Horng-Yih& Feng, Wei& Chuang, Lee-Ming& Chiu, Ken C.…[et al.]. 2016. Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108192
Modern Language Association (MLA)
Karnchanasorn, Rudruidee…[et al.]. Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108192
American Medical Association (AMA)
Karnchanasorn, Rudruidee& Huang, Jean& Ou, Horng-Yih& Feng, Wei& Chuang, Lee-Ming& Chiu, Ken C.…[et al.]. Comparison of the Current Diagnostic Criterion of HbA1c with Fasting and 2-Hour Plasma Glucose Concentration. Journal of Diabetes Research. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108192
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108192