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The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats
Joint Authors
Martínez Martínez, Alejandro
Martínez-Ladrón de Guevara, Elideth
Pérez-Hernández, Nury
Villalobos-López, Miguel Ángel
Pérez-Ishiwara, David Guillermo
Hernández-García, Vicente
Salas-Benito, Juan Santiago
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This study was designed to examine the effects of lyophilized red delicious apple peel (RDP) on the action potentials (APs) and the input resistance-threshold current relationship.
The experiments were performed on isolated papillary heart muscles from healthy male rats, healthy male rats treated with RDP, diabetic male rats, and diabetic male rats treated with RDP.
The preparation was superfused with oxygenated Tyrode’s solution at 37°C.
The stimulation and the recording of the APs, the input resistance, and the threshold current were made using conventional electrophysiological methods.
The RDP presented no significant effect in normal rats.
Equivalent doses in diabetic rats reduced the APD and ARP.
The relationship between input resistance and threshold current established an inverse correlation.
The results indicate the following: (1) The functional structure of the cardiac ventricular syncytium in healthy rats is heterogeneous, in terms of input resistance and threshold current.
Diabetes further accentuates the heterogeneity.
(2) As a consequence, conduction block occurs and increases the possibility of reentrant arrhythmias.
(3) These modifications in the ventricular syncytium, coupled with the increase in the ARP, are the adequate substrate so that, with diabetes, the heart becomes more arrhythmogenic.
(4) RDP decreases the APD, the ARP, and most syncytium irregularity caused by diabetes.
American Psychological Association (APA)
Martínez-Ladrón de Guevara, Elideth& Pérez-Hernández, Nury& Villalobos-López, Miguel Ángel& Pérez-Ishiwara, David Guillermo& Salas-Benito, Juan Santiago& Martínez Martínez, Alejandro…[et al.]. 2015. The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108269
Modern Language Association (MLA)
Martínez-Ladrón de Guevara, Elideth…[et al.]. The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108269
American Medical Association (AMA)
Martínez-Ladrón de Guevara, Elideth& Pérez-Hernández, Nury& Villalobos-López, Miguel Ángel& Pérez-Ishiwara, David Guillermo& Salas-Benito, Juan Santiago& Martínez Martínez, Alejandro…[et al.]. The Actions of Lyophilized Apple Peel on the Electrical Activity and Organization of the Ventricular Syncytium of the Hearts of Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108269
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108269