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Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research)
Joint Authors
Yang, Guang
Li, Chunlin
Gong, Yanping
Fang, Fusheng
Tian, Hui
Li, Jian
Cheng, Xiaoling
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Aim.
To evaluate the differences in insulin resistance (IR) among subjects with normal glucose tolerance (NGT), hyperinsulinemia with NGT (HINS), impaired glucose tolerance (IGT), and newly diagnosed type 2 diabetes mellitus (T2DM).
Methods.
5 NGT, 25 HINS, 25 IGT, and 25 T2DM subjects participated in this research.
The hyperinsulinemic-euglycemic clamp technique (HECT) was performed in all of them to evaluate IR levels.
The relative factors influencing IR were evaluated.
The simple insulin sensitivity indices were calculated, and the correlation between each index and the M value was analyzed.
Results.
The M values of NGT, HINS, IGT, and T2DM groups were 11.88 ± 2.93 mg·kg−1·min−1, 6.23 ± 1.73 mg·kg−1·min−1, 6.37 ± 2.12 mg·kg−1·min−1, and 6.19 ± 1.89 mg·kg−1·min−1, respectively.
M values in HINS, IGT, and T2DM groups were lower than those in the NGT group (P=0.005); however, the differences among the HINS, IGT, and T2DM groups were not statistically significant (P=0.835).
The independent factors influencing the M value were waistline and fasting insulin level (FINS).
The simple insulin sensitivity indices, especially Matsuda and Gutt index, were significantly associated with the M value (P<0.01).
Conclusion.
IR existed in the HINS, IGT, and T2DM groups, and IR levels were consistent in the three groups.
The independent factors influencing IR were waistline and FINS.
American Psychological Association (APA)
Yang, Guang& Li, Chunlin& Gong, Yanping& Fang, Fusheng& Tian, Hui& Li, Jian…[et al.]. 2015. Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research). Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108323
Modern Language Association (MLA)
Yang, Guang…[et al.]. Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research). Journal of Diabetes Research No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1108323
American Medical Association (AMA)
Yang, Guang& Li, Chunlin& Gong, Yanping& Fang, Fusheng& Tian, Hui& Li, Jian…[et al.]. Assessment of Insulin Resistance in Subjects with Normal Glucose Tolerance, Hyperinsulinemia with Normal Blood Glucose Tolerance, Impaired Glucose Tolerance, and Newly Diagnosed Type 2 Diabetes (Prediabetes Insulin Resistance Research). Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1108323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108323