Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

Abstract EN

Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients.

Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications.

The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats.

Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats.

Wounds from diabetic rats were treated with 10% hemin ointment for 21 days.

Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats.

Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein.

In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.