Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats
Joint Authors
Chen, Qing-Ying
Li, Wei
Jiang, Yu-Xin
Lu, Xiao-Hua
Zhou, Ping-Ping
Wang, Guo Guang
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2015-12-20
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients.
Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications.
The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats.
Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats.
Wounds from diabetic rats were treated with 10% hemin ointment for 21 days.
Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats.
Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein.
In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
American Psychological Association (APA)
Chen, Qing-Ying& Wang, Guo Guang& Li, Wei& Jiang, Yu-Xin& Lu, Xiao-Hua& Zhou, Ping-Ping. 2015. Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108338
Modern Language Association (MLA)
Chen, Qing-Ying…[et al.]. Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108338
American Medical Association (AMA)
Chen, Qing-Ying& Wang, Guo Guang& Li, Wei& Jiang, Yu-Xin& Lu, Xiao-Hua& Zhou, Ping-Ping. Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats. Journal of Diabetes Research. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108338