The LINA Study: Higher Sensitivity of Infant Compared to Maternal EosinophilBasophil Progenitors to Indoor Chemical Exposures
Joint Authors
Simon, Jan C.
Lehmann, Irina
Herberth, Gunda
Hörnig, Friederike
Kohajda, Tibor
Röder, Stefan
Borte, Michael
Diez, Ulrike
Rolle-Kampczyk, Ulrike
Denburg, Judah A.
Junge, Kristin M.
von Bergen, Martin
Source
Journal of Environmental and Public Health
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
Enhanced eosinophil/basophil (Eo/B) progenitor cell levels are known to be associated with allergic inflammation and atopy risk.
The aim of the present study was to investigate the influence of different indoor exposures on the recruitment and differentiation of Eo/B progenitors in mother-child pairs.
Methods.
In 68 mother-child pairs of the LINA study peripheral blood mononuclear cells were used to assess Eo/B colony forming units (CFUs).
Information about disease outcomes and indoor exposures was obtained from questionnaires.
Indoor concentrations of volatile organic compounds (VOCs) were measured by passive sampling.
Results.
Infant’s Eo/B CFUs were positively associated with exposure to tobacco smoke, disinfectants, or VOCs.
In contrast, for maternal Eo/B CFUs, only a few associations were seen.
Higher numbers of infant Eo/B CFUs were observed in children with wheezing symptoms within the second year of life.
Conclusions.
We demonstrate that infant’s hematopoietic cells seem to respond with more sensitivity to environmental exposure compared to maternal cells.
At least in infants, an activation of these hematopoietic cells by environmental exposure could contribute to an enhanced risk for the development of respiratory outcomes.
American Psychological Association (APA)
Hörnig, Friederike& Kohajda, Tibor& Röder, Stefan& Herberth, Gunda& von Bergen, Martin& Borte, Michael…[et al.]. 2016. The LINA Study: Higher Sensitivity of Infant Compared to Maternal EosinophilBasophil Progenitors to Indoor Chemical Exposures. Journal of Environmental and Public Health،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108525
Modern Language Association (MLA)
Hörnig, Friederike…[et al.]. The LINA Study: Higher Sensitivity of Infant Compared to Maternal EosinophilBasophil Progenitors to Indoor Chemical Exposures. Journal of Environmental and Public Health No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1108525
American Medical Association (AMA)
Hörnig, Friederike& Kohajda, Tibor& Röder, Stefan& Herberth, Gunda& von Bergen, Martin& Borte, Michael…[et al.]. The LINA Study: Higher Sensitivity of Infant Compared to Maternal EosinophilBasophil Progenitors to Indoor Chemical Exposures. Journal of Environmental and Public Health. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1108525
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108525