Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations
Joint Authors
Xu, Jian
Cheng, Yuqi
Lai, Aiyun
Bai, Ru
Liu, Shuang
Zhao, Yueyin
Li, Shu
Xie, Zhongqi
Xu, Xinyu
Lu, Zhaoping
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Depressive and anxiety disorders are frequently observed in patients with Systemic Lupus Erythematosus (SLE).
However, the underlying mechanisms are still unknown.
We conducted this survey to understand the prevalence of depression and anxiety in SLE patients without major neuropsychiatric manifestations (non-NPSLE) and to explore the relationship between emotional disorders, symptoms, autoantibodies, disease activity, and treatments in SLE.
176 SLE patients were included, and SLE disease activity index (SLEDAI), Hamilton Depression Rating Scale (HAMD), and Hamilton Anxiety Rating Scale (HAMA) were recorded to evaluate their disease activity and emotional status.
We found that depressive and anxiety disorders were common among SLE patients: 121 (68.8%) patients were in depression status while 14 (8.0%) patients could be diagnosed with depression.
Accordingly, 101 (57.4%) were in anxiety status and 21 (11.9%) could be diagnosed with anxiety.
Depression was associated with disease activity, and anxiety was associated with anti-P0 antibody, while both of them were associated with proteinuria.
HAMA and HAMD scores were in strong positive correlation and they were independent risk factors of each other.
We concluded that the high prevalence of depression and anxiety and the association between depression and SLE disease activity might reveal the covert damage of central nervous system in SLE.
The role of anti-P0 antibody in SLE patients with emotional disorders warrants more researches.
American Psychological Association (APA)
Bai, Ru& Liu, Shuang& Zhao, Yueyin& Cheng, Yuqi& Li, Shu& Lai, Aiyun…[et al.]. 2016. Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108745
Modern Language Association (MLA)
Bai, Ru…[et al.]. Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1108745
American Medical Association (AMA)
Bai, Ru& Liu, Shuang& Zhao, Yueyin& Cheng, Yuqi& Li, Shu& Lai, Aiyun…[et al.]. Depressive and Anxiety Disorders in Systemic Lupus Erythematosus Patients without Major Neuropsychiatric Manifestations. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1108745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108745