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Immunomodulatory Effects Mediated by Dopamine
Joint Authors
De La Cruz-Aguilera, Dora Luz
Hurtado-Alvarado, Gabriela
Quintero-Fabián, Saray
Becerril, Enrique
Arreola, Rodrigo
Cruz-Fuentes, Carlos
Garcés-Alvarez, María Eugenia
Flores-Gutiérrez, Enrique Octavio
Pérez-Sánchez, Gilberto
Alvarez-Herrera, Samantha
Medina-Rivero, Emilio
Pavon, Lenin
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-31, 31 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
31
Main Subjects
Abstract EN
Dopamine (DA), a neurotransmitter in the central nervous system (CNS), has modulatory functions at the systemic level.
The peripheral and central nervous systems have independent dopaminergic system (DAS) that share mechanisms and molecular machinery.
In the past century, experimental evidence has accumulated on the proteins knowledge that is involved in the synthesis, reuptake, and transportation of DA in leukocytes and the differential expression of the D1-like (D1R and D5R) and D2-like receptors (D2R, D3R, and D4R).
The expression of these components depends on the state of cellular activation and the concentration and time of exposure to DA.
Receptors that are expressed in leukocytes are linked to signaling pathways that are mediated by changes in cAMP concentration, which in turn triggers changes in phenotype and cellular function.
According to the leukocyte lineage, the effects of DA are associated with such processes as respiratory burst, cytokine and antibody secretion, chemotaxis, apoptosis, and cytotoxicity.
In clinical conditions such as schizophrenia, Parkinson disease, Tourette syndrome, and multiple sclerosis (MS), there are evident alterations during immune responses in leukocytes, in which changes in DA receptor density have been observed.
Several groups have proposed that these findings are useful in establishing clinical status and clinical markers.
American Psychological Association (APA)
Arreola, Rodrigo& Alvarez-Herrera, Samantha& Pérez-Sánchez, Gilberto& Becerril, Enrique& Cruz-Fuentes, Carlos& Flores-Gutiérrez, Enrique Octavio…[et al.]. 2016. Immunomodulatory Effects Mediated by Dopamine. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1108758
Modern Language Association (MLA)
Arreola, Rodrigo…[et al.]. Immunomodulatory Effects Mediated by Dopamine. Journal of Immunology Research No. 2016 (2016), pp.1-31.
https://search.emarefa.net/detail/BIM-1108758
American Medical Association (AMA)
Arreola, Rodrigo& Alvarez-Herrera, Samantha& Pérez-Sánchez, Gilberto& Becerril, Enrique& Cruz-Fuentes, Carlos& Flores-Gutiérrez, Enrique Octavio…[et al.]. Immunomodulatory Effects Mediated by Dopamine. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-31.
https://search.emarefa.net/detail/BIM-1108758
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108758