Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews
Joint Authors
Li, You-Ping
Zhou, Yanni
Shan, Juan
Guo, Yingjia
Li, Shengfu
Long, Dan
Feng, Li
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-28
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
Objective.
To dissect the efficacy of Tol-DC therapy with or without IS in multiple animal models of transplantation.
Methods and Results.
PubMed, Medline, Embase, and the Cochrane Library were searched for reviews published up to April 2015.
Six systematic reviews and a total of 61 articles were finally included.
Data were grouped by organ transplantation models and applied to meta-analysis.
Our meta-analysis shows that Tol-DC therapy successfully prolonged allograft survival to varying extents in all except the islet transplantation models and with IS drugs further prolonged the survival of heart, skin, and islet allografts in mice, but not of heart allografts in rats.
Compared with IS drugs alone, Tol-DC therapy with IS extended islet allograft survival in rats but failed to influence the survival of skin, small intestine, and heart allografts in rats or of heart and skin allografts in mice.
Conclusion.
Tol-DC therapy significantly prolonged multiple allograft survival and further prolonged survival with IS.
However, standardized protocols for modification of Tol-DC should be established before its application in clinic.
American Psychological Association (APA)
Zhou, Yanni& Shan, Juan& Guo, Yingjia& Li, Shengfu& Long, Dan& Li, You-Ping…[et al.]. 2016. Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108832
Modern Language Association (MLA)
Zhou, Yanni…[et al.]. Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews. Journal of Immunology Research No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1108832
American Medical Association (AMA)
Zhou, Yanni& Shan, Juan& Guo, Yingjia& Li, Shengfu& Long, Dan& Li, You-Ping…[et al.]. Effects of Adoptive Transfer of Tolerogenic Dendritic Cells on Allograft Survival in Organ Transplantation Models: An Overview of Systematic Reviews. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1108832
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108832