Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis
Joint Authors
López-Romero, Everardo
Alba-Fierro, Carlos A.
Pérez-Torres, Armando
Toriello, Conchita
Pulido-Camarillo, Evelyn
Romo-Lozano, Yolanda
Gutiérrez-Sánchez, Gerardo
Ruiz-Baca, Estela
Source
Journal of Immunology Research
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-14
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Cell wall (CW) components of fungus Sporothrix schenckii are the major inductors antigens of immune responses.
The immunodominant 60 kDa glycoprotein (gp60) has been shown to be associated with the virulence of this fungus but its role in experimental sporotrichosis is unknown.
In this work, the immunological effects of CW-purified gp60 were investigated in a model of experimental subcutaneous sporotrichosis in normal and gp60-preimmunized C57BL/6 and BALB/c mice strains which were then infected with S.
schenckii conidia.
Results showed that both mice strains use different cytokine profiles in order to fight S.
schenckii infection; C57BL/6 mice seem to use a Th17 response while BALB/c mice tend to depend on a Th1 profile.
Preimmunization with gp60 showed a downregulatory effect on the immune response since cytokines levels were diminished in both strains.
There were no significant differences in the magnitude of dorsoplantar inflammation between gp60-preimmunized and nonimmunized mice of both strains.
However, skin lesions due to the infection in gp60-preimmunized mice were more severe in BALB/c than in C57BL/6 mice, suggesting that the antigen exerts a higher downregulatory effect on the Th1 response.
American Psychological Association (APA)
Alba-Fierro, Carlos A.& Pérez-Torres, Armando& Toriello, Conchita& Pulido-Camarillo, Evelyn& López-Romero, Everardo& Romo-Lozano, Yolanda…[et al.]. 2016. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
Modern Language Association (MLA)
Alba-Fierro, Carlos A.…[et al.]. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
American Medical Association (AMA)
Alba-Fierro, Carlos A.& Pérez-Torres, Armando& Toriello, Conchita& Pulido-Camarillo, Evelyn& López-Romero, Everardo& Romo-Lozano, Yolanda…[et al.]. Immune Response Induced by an Immunodominant 60 kDa Glycoprotein of the Cell Wall of Sporothrix schenckii in Two Mice Strains with Experimental Sporotrichosis. Journal of Immunology Research. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1108846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1108846