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Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea)
Joint Authors
Kano, Shunsuke
Komada, Haruna
Yonekura, Lina
Sato, Akihiko
Nishiwaki, Hisashi
Tamura, Hirotoshi
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-01-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Absorption, metabolism, and excretion of 3,4-DHPEA-EDA, oleuropein, and hydroxytyrosol isolated from olive fruits were newly evaluated after oral and intravenous administration in freely moving rats cannulated in the portal vein, jugular vein, and bile duct.
Orally administered 3,4-DHPEA-EDA, an important bioactive compound in olive pomace, was readily absorbed and metabolized to hydroxytyrosol, homovanillic acid, and homovanillyl alcohol, as shown by dose-normalized 4 h area under the curve ( A U C 0 → 4 h /Dose) values of 27.7, 4.5, and 4.2 μM·min·kg/μmol, respectively, in portal plasma after oral administration.
The parent compound 3,4-DHPEA-EDA was not observed in the portal plasma, urine, and bile after oral and intravenous administration.
Additionally, hydroxytyrosol, homovanillic acid, and homovanillyl alcohol in the portal plasma after oral administration of hydroxytyrosol showed 51.1, 22.8, and 7.1 μM·min·kg/μmol A U C 0 → 4 h /Dose, respectively.
When oleuropein, a polar glucoside, was injected orally, oleuropein in the portal plasma showed 0.9 μM·min·kg/μmol A U C 0 → 4 h /Dose.
However, homovanillic acid was detected from oleuropein in only a small amount in the portal plasma.
Moreover, the bioavailability of hydroxytyrosol and oleuropein for 4 hours was 13.1% and 0.5%, respectively.
Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities.
American Psychological Association (APA)
Kano, Shunsuke& Komada, Haruna& Yonekura, Lina& Sato, Akihiko& Nishiwaki, Hisashi& Tamura, Hirotoshi. 2016. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
Modern Language Association (MLA)
Kano, Shunsuke…[et al.]. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
American Medical Association (AMA)
Kano, Shunsuke& Komada, Haruna& Yonekura, Lina& Sato, Akihiko& Nishiwaki, Hisashi& Tamura, Hirotoshi. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109618