Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea)
المؤلفون المشاركون
Kano, Shunsuke
Komada, Haruna
Yonekura, Lina
Sato, Akihiko
Nishiwaki, Hisashi
Tamura, Hirotoshi
المصدر
Journal of Nutrition and Metabolism
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-19
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Absorption, metabolism, and excretion of 3,4-DHPEA-EDA, oleuropein, and hydroxytyrosol isolated from olive fruits were newly evaluated after oral and intravenous administration in freely moving rats cannulated in the portal vein, jugular vein, and bile duct.
Orally administered 3,4-DHPEA-EDA, an important bioactive compound in olive pomace, was readily absorbed and metabolized to hydroxytyrosol, homovanillic acid, and homovanillyl alcohol, as shown by dose-normalized 4 h area under the curve ( A U C 0 → 4 h /Dose) values of 27.7, 4.5, and 4.2 μM·min·kg/μmol, respectively, in portal plasma after oral administration.
The parent compound 3,4-DHPEA-EDA was not observed in the portal plasma, urine, and bile after oral and intravenous administration.
Additionally, hydroxytyrosol, homovanillic acid, and homovanillyl alcohol in the portal plasma after oral administration of hydroxytyrosol showed 51.1, 22.8, and 7.1 μM·min·kg/μmol A U C 0 → 4 h /Dose, respectively.
When oleuropein, a polar glucoside, was injected orally, oleuropein in the portal plasma showed 0.9 μM·min·kg/μmol A U C 0 → 4 h /Dose.
However, homovanillic acid was detected from oleuropein in only a small amount in the portal plasma.
Moreover, the bioavailability of hydroxytyrosol and oleuropein for 4 hours was 13.1% and 0.5%, respectively.
Because the amount of 3,4-DHPEA-EDA in olive fruits is about 2-3 times greater than that of hydroxytyrosol, the metabolites of 3,4-DHPEA-EDA will influence biological activities.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kano, Shunsuke& Komada, Haruna& Yonekura, Lina& Sato, Akihiko& Nishiwaki, Hisashi& Tamura, Hirotoshi. 2016. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kano, Shunsuke…[et al.]. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kano, Shunsuke& Komada, Haruna& Yonekura, Lina& Sato, Akihiko& Nishiwaki, Hisashi& Tamura, Hirotoshi. Absorption, Metabolism, and Excretion by Freely Moving Rats of 3,4-DHPEA-EDA and Related Polyphenols from Olive Fruits (Olea europaea). Journal of Nutrition and Metabolism. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1109618
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1109618
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر