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Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience
Joint Authors
Jacob, Linu A.
Lokanatha, D.
Babu, Govind
Babu, Suresh
Kumar, Rekha V.
Lokesh, K. N.
Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa
Kamath, Mangesh
Rajeev, Lakkavalli Krishnappa
Haleshappa, Rudresha Antapura
Saldanha, Smitha Carol
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Purpose.
Neuroendocrine neoplasms (NENs) of the esophagus are very uncommon with only a few studies published worldwide.
Studies on clinical profile, management, and outcomes are very uncommon.
Methods.
We report the largest single institution retrospective review of 43 patients of pure esophageal NENs out of our registry of gastrointestinal neuroendocrine tumors treated between 2005 and 2014.
Data on the incidence, tumor location, clinical symptoms, stage at presentation, grading, treatment protocol, and treatment outcomes was collected and analyzed.
Results.
Among 1293 cases of esophageal cancers, pure esophageal NENs were diagnosed in 43 cases.
The mean patient age was 55.8 years.
The male : female ratio was 1.5 : 1.
81.4% of the tumors were located in the lower third of the esophagus and gastroesophageal junction.
Neuroendocrine carcinomas (NEC; G3) accounted for the vast majority of NENs (83.7%).
53.5% patients were Stage IV and 32.5% were Stage III at presentation.
The combined median survival of stages II and III patients was 18.25 months, with treatment.
The median survival of treated patients with metastatic disease was 6.5 months.
Conclusion.
Esophageal NENs most commonly were neuroendocrine carcinomas, presented in metastatic stage and were associated with poor prognosis.
Grade 2 (G2) tumors had better outcomes than NEC (G3).
In nonmetastatic disease, presence of lymph node metastasis and unresectable disease had poorer outcomes.
American Psychological Association (APA)
Babu, Govind& Lokanatha, D.& Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa& Kamath, Mangesh& Jacob, Linu A.& Babu, Suresh…[et al.]. 2016. Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience. Journal of Oncology،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109690
Modern Language Association (MLA)
Babu, Govind…[et al.]. Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience. Journal of Oncology No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1109690
American Medical Association (AMA)
Babu, Govind& Lokanatha, D.& Lakshmaiah, Kuntegowdanahalli Chinnagiriyappa& Kamath, Mangesh& Jacob, Linu A.& Babu, Suresh…[et al.]. Clinicopathological Profile of Pure Neuroendocrine Neoplasms of the Esophagus: A South Indian Center Experience. Journal of Oncology. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1109690
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1109690