![](/images/graphics-bg.png)
Antimicrobial Activity of Croton macrostachyus Stem Bark Extracts against Several Human Pathogenic Bacteria
Joint Authors
von Wright, Atte
Obey, Jackie K.
Orjala, Jimmy
Tikkanen-Kaukanen, Carina
Kauhanen, Jussi
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-11
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
In Kenya, leaves and roots from Croton macrostachyus are used as a traditional medicine for infectious diseases such as typhoid and measles, but reports on possible antimicrobial activity of stem bark do not exist.
In this study, the antibacterial and antifungal effects of methanol, ethyl acetate and butanol extracts, and purified lupeol of C.
macrostachyus stem bark were determined against important human gram-negative pathogens Escherichia coli, Salmonella typhi, Klebsiella pneumoniae, and Enterobacter aerogenes, gram-positive Listeria monocytogenes, and a fungus Candida albicans.
The most promising broad scale antimicrobial activity against all the studied pathogens was shown by the ethyl acetate extract.
The ethyl acetate extract induced the zone of inhibition between 10.1 ± 0.6 mm and 16.0 ± 1.2 mm against S.
typhi, E.
coli, K.
pneumoniae, E.
aerogenes, and L.
monocytogenes with weaker antimicrobial activity against C.
albicans (zone of inhibition: 5.6 ± 1.0 mm).
The antibiotic controls (amoxicillin, ciprofloxacin, ampicillin, benzylpenicillin, clotrimazole, and cefotaxime) showed antimicrobial activity with zones of inhibition within 13.4 ± 0.7 – 22.1 ± 0.9 mm.
The ethyl acetate extract had MIC in the range of 125–250 mg/mL against all the studied bacteria and against C.
albicans MIC was 500 mg/mL.
The present results give scientific evidence and support the traditional use of C.
macrostachyus stem bark as a source for antimicrobials.
We show that C.
macrostachyus stem bark lupeol is a promising antimicrobial agent against several important human pathogens.
American Psychological Association (APA)
Obey, Jackie K.& von Wright, Atte& Orjala, Jimmy& Kauhanen, Jussi& Tikkanen-Kaukanen, Carina. 2016. Antimicrobial Activity of Croton macrostachyus Stem Bark Extracts against Several Human Pathogenic Bacteria. Journal of Pathogens،Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110197
Modern Language Association (MLA)
Obey, Jackie K.…[et al.]. Antimicrobial Activity of Croton macrostachyus Stem Bark Extracts against Several Human Pathogenic Bacteria. Journal of Pathogens No. 2016 (2016), pp.1-5.
https://search.emarefa.net/detail/BIM-1110197
American Medical Association (AMA)
Obey, Jackie K.& von Wright, Atte& Orjala, Jimmy& Kauhanen, Jussi& Tikkanen-Kaukanen, Carina. Antimicrobial Activity of Croton macrostachyus Stem Bark Extracts against Several Human Pathogenic Bacteria. Journal of Pathogens. 2016. Vol. 2016, no. 2016, pp.1-5.
https://search.emarefa.net/detail/BIM-1110197
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110197