The Relationship between Population T4TSH Set Point Data and T4TSH Physiology
Joint Authors
Fitzgerald, Stephen Paul
Bean, Nigel Geoffrey
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Context.
Population studies of the distribution of T4/TSH set points suggest a more complex inverse relationship between T4 and TSH than that suggested by physiological studies.
The reasons for the similarities and differences between the curves describing these relationships are unresolved.
Methods.
We subjected the curve, derived from empiric data, describing the TSH suppression response to T4, and the more mathematically derived curve describing the T4 response to TSH, to the different possible models of population variation.
The implied consequences of these in terms of generating a population distribution of T4/TSH equilibrium points (a “population curve”) were generated and compared to the empiric population curve.
The physiological responses to primary hypothyroidism and hyperthyroidism were incorporated into the analysis.
Conclusions.
Though the population curve shows a similarly inverse relationship, it is describing a different relationship than the curve describing the suppression of TSH by T4.
The population curve is consistent with the physiological studies of the TSH response to T4 and implies a greater interindividual variation in the positive thyroid T4 response to TSH than in the central inhibitory TSH response to T4.
The population curve in the dysthyroid states is consistent with known physiological responses to these states.
American Psychological Association (APA)
Fitzgerald, Stephen Paul& Bean, Nigel Geoffrey. 2016. The Relationship between Population T4TSH Set Point Data and T4TSH Physiology. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110879
Modern Language Association (MLA)
Fitzgerald, Stephen Paul& Bean, Nigel Geoffrey. The Relationship between Population T4TSH Set Point Data and T4TSH Physiology. Journal of Thyroid Research No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1110879
American Medical Association (AMA)
Fitzgerald, Stephen Paul& Bean, Nigel Geoffrey. The Relationship between Population T4TSH Set Point Data and T4TSH Physiology. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1110879
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110879