Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism
Joint Authors
Nitert, Marloes Dekker
Richard, Kerry
Molehin, Deborah
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-17
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Background.
Thyroid hormones (THs) are essential for normal human fetal development and play a major role in the regulation of glucose and lipid metabolism.
Delivery of TH to target tissues is dependent on processes including TH synthesis, transport, and metabolism.
Thyroid hormone endocrine disruptors (TH-EDCs) are chemical substances that interfere with these processes, potentially leading to adverse pregnancy outcomes.
Objectives.
This review focuses on the effects of prenatal exposures to combinations of TH-EDCs on fetal and neonatal glucose and lipid metabolism and also discusses the various mechanisms by which TH-EDCs interfere with other hormonal pathways.
Methods.
We conducted a comprehensive narrative review on the effects of TH-EDCs with particular emphasis on exposure during pregnancy.
Discussion.
TH imbalance has been linked to many metabolic processes and the effects of TH imbalance are particularly pronounced in early fetal development due to fetal dependence on maternal TH for proper growth and development.
The pervasive presence of EDCs in the environment results in ubiquitous exposure to either single or mixtures of EDCs with deleterious effects on metabolism.
Conclusions.
Further evaluation of combined effects of TH-EDCs on fetal metabolic endpoints could improve advice provided to expectant mothers.
American Psychological Association (APA)
Molehin, Deborah& Nitert, Marloes Dekker& Richard, Kerry. 2016. Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110883
Modern Language Association (MLA)
Molehin, Deborah…[et al.]. Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism. Journal of Thyroid Research No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1110883
American Medical Association (AMA)
Molehin, Deborah& Nitert, Marloes Dekker& Richard, Kerry. Prenatal Exposures to Multiple Thyroid Hormone Disruptors: Effects on Glucose and Lipid Metabolism. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1110883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110883