Change in Practice over Four Decades in the Management of Graves’ Disease in Scotland
Joint Authors
Thaha, M. A.
Smith, D. M.
Dutta, S.
Ahmed, F.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-05-30
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
There is continuing debate on the optimal treatment for Grave’s thyrotoxicosis with a resultant variation in clinical practice.
The present study aimed to ascertain changes in practice in the treatment of Grave’s thyrotoxicosis in Tayside, Scotland, over the past four decades.
Methods.
The “Scottish automated follow-up register” (SAFUR) was queried to identify all patients treated for Grave’s thyrotoxicosis from 1968 to 2007 inclusive.
Patients were divided into 4 groups (Groups A to D) according to the decades.
Demographic profile, treatment modalities, radioactive iodine (RAI) dose, and recurrence rates were studied and outcomes were compared by χ 2 test and ANOVA using SPSS v15.0.
A p value of < 0.05 was considered significant.
Results.
Altogether, 3737 patients were diagnosed with Grave’s thyrotoxicosis over the 4 decades.
Use of RAI has increased from 43.1% in Group A to 68% in Group D ( p < 0.001 ).
The dose of RAI has increased ( p < 0.001 ) and there has been a reduction in recurrence rate with higher dose of RAI.
Surgical intervention rates decreased from 55.3% to 12.3% ( p < 0.001 ) over time.
Conclusions.
Analysis of a large dataset of patients with Grave’s thyrotoxicosis suggests increasing use of RAI as the preferred first line of treatment.
Furthermore, using a single higher dose of RAI and adoption of total thyroidectomy have decreased recurrence rates.
American Psychological Association (APA)
Smith, D. M.& Dutta, S.& Ahmed, F.& Thaha, M. A.. 2016. Change in Practice over Four Decades in the Management of Graves’ Disease in Scotland. Journal of Thyroid Research،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110885
Modern Language Association (MLA)
Smith, D. M.…[et al.]. Change in Practice over Four Decades in the Management of Graves’ Disease in Scotland. Journal of Thyroid Research No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1110885
American Medical Association (AMA)
Smith, D. M.& Dutta, S.& Ahmed, F.& Thaha, M. A.. Change in Practice over Four Decades in the Management of Graves’ Disease in Scotland. Journal of Thyroid Research. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1110885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1110885