NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula
Joint Authors
Gong, Chenyuan
Luo, Yingbin
Wu, Jianchun
Zhu, Xiaowen
Yao, Chao
Ni, Zhongya
Wang, Lixin
Ni, Lulu
Li, Yan
Zhu, Shiguo
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-02-29
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC).
Here, we found that YPF significantly inhibited the growth of Lewis lung cancer, prolonged the survival of tumor-bearing mice, promoted NK cell tumor infiltration, increased the population of NK cells in spleen, and enhanced NK cell-mediated killing activity.
The growth suppression of tumors by YPF was significantly reversed by the depletion of NK cells.
Furthermore, we found that YPF significantly downregulated the expression of TGF-β, indoleamine 2,3-dioxygenase, and IL-10 in tumor microenvironment.
These results demonstrated that YPF has a NK cell-dependent inhibitory effect on Lewis lung cancer.
American Psychological Association (APA)
Luo, Yingbin& Wu, Jianchun& Zhu, Xiaowen& Gong, Chenyuan& Yao, Chao& Ni, Zhongya…[et al.]. 2016. NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111016
Modern Language Association (MLA)
Luo, Yingbin…[et al.]. NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula. Mediators of Inflammation No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1111016
American Medical Association (AMA)
Luo, Yingbin& Wu, Jianchun& Zhu, Xiaowen& Gong, Chenyuan& Yao, Chao& Ni, Zhongya…[et al.]. NK Cell-Dependent Growth Inhibition of Lewis Lung Cancer by Yu-Ping-Feng, an Ancient Chinese Herbal Formula. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1111016
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111016