CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation
Joint Authors
Soldevila, Gloria
López-Pacheco, C.
Du Pont, G.
Hernández-Pando, Rogelio
García-Zepeda, E. A.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-04
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Airway inflammation is the most common hallmark of allergic asthma.
Chemokine receptors involved in leukocyte recruitment are closely related to the pathology in asthma.
CCR9 has been described as a homeostatic and inflammatory chemokine receptor, but its role and that of its ligand CCL25 during lung inflammation remain unknown.
To investigate the role of CCR9 as a modulator of airway inflammation, we established an OVA-induced allergic inflammation model in CCR9-deficient mice.
Here, we report the expression of CCR9 and CCL25 as early as 6 hours post-OVA challenge in eosinophils and T-lymphocytes.
Moreover, in challenged CCR9-deficient mice, cell recruitment was impaired at peribronchial and perivenular levels.
OVA-administration in CCR9-deficient mice leads to a less inflammatory cell recruitment, which modifies the expression of IL-10, CCL11, and CCL25 at 24 hours after OVA challenge.
In contrast, the secretion of IL-4 and IL-5 was not affected in CCR9-deficient mice compared to WT mice.
These results demonstrate for the first time that CCR9 and CCL25 expressions are induced in the early stages of airway inflammation and they have an important role modulating eosinophils and lymphocytes recruitment at the first stages of inflammatory process, suggesting that they might be a potential target to regulate inflammation in asthma.
American Psychological Association (APA)
López-Pacheco, C.& Soldevila, Gloria& Du Pont, G.& Hernández-Pando, Rogelio& García-Zepeda, E. A.. 2016. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
Modern Language Association (MLA)
López-Pacheco, C.…[et al.]. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation No. 2016 (2016), pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
American Medical Association (AMA)
López-Pacheco, C.& Soldevila, Gloria& Du Pont, G.& Hernández-Pando, Rogelio& García-Zepeda, E. A.. CCR9 Is a Key Regulator of Early Phases of Allergic Airway Inflammation. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1111024
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111024