![](/images/graphics-bg.png)
Sex Hormones Enhance Gingival Inflammation without Affecting IL-1β and TNF-α in Periodontally Healthy Women during Pregnancy
Joint Authors
Wu, Min
Chen, Shao-Wu
Jiang, Shao-Yun
Su, Wei-Lan
Zhu, Hong-Ying
Ouyang, Shu-Yuan
Cao, Ya-Ting
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-01
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hormones (progesterone and estradiol) change greatly during pregnancy; however, the mechanism of hormonal changes on gingival inflammation is still unclear.
This study is to evaluate the effects of hormonal changes during pregnancy on gingival inflammation and interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in gingival crevicular fluid (GCF).
30 periodontally healthy pregnant women were evaluated in the first, second, and third trimesters.
20 periodontally healthy nonpregnant women were evaluated twice (once per subsequent month).
Clinical parameters including probing pocket depth (PPD), bleeding index (BI), gingival index (GI), clinical attachment level (CAL), and plaque index (PLI) were recorded.
GCF levels of IL-1β and TNF-α and serum levels of progesterone and estradiol were measured.
From the data, despite low PLI, BI and GI increased significantly during pregnancy; however, no significant changes in PLI, CAL, IL-1β, or TNF-α GCF levels were observed.
Although IL-1β, not TNF-α, was higher in pregnant group than in nonpregnant group, they showed no correlation with serum hormone levels during pregnancy.
GI and BI showed significant positive correlation with serum hormone levels during pregnancy.
This study suggests that sex hormone increase during pregnancy might have an effect on inflammatory status of gingiva, independent of IL-1β and TNF-α in GCF.
American Psychological Association (APA)
Wu, Min& Chen, Shao-Wu& Su, Wei-Lan& Zhu, Hong-Ying& Ouyang, Shu-Yuan& Cao, Ya-Ting…[et al.]. 2016. Sex Hormones Enhance Gingival Inflammation without Affecting IL-1β and TNF-α in Periodontally Healthy Women during Pregnancy. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111078
Modern Language Association (MLA)
Wu, Min…[et al.]. Sex Hormones Enhance Gingival Inflammation without Affecting IL-1β and TNF-α in Periodontally Healthy Women during Pregnancy. Mediators of Inflammation No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1111078
American Medical Association (AMA)
Wu, Min& Chen, Shao-Wu& Su, Wei-Lan& Zhu, Hong-Ying& Ouyang, Shu-Yuan& Cao, Ya-Ting…[et al.]. Sex Hormones Enhance Gingival Inflammation without Affecting IL-1β and TNF-α in Periodontally Healthy Women during Pregnancy. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1111078
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111078