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Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease
Joint Authors
Carvajal, Karla
Phillips-Farfán, Bryan
Medina-Torres, Edgar Alejandro
Espinosa-Padilla, Sara Elva
Fabrias, Gemma
Camacho, Luz
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Inflammatory bowel disease (IBD) describes different illnesses characterized by chronic inflammation of the gastrointestinal tract.
Although the pathogenic mechanisms leading to IBD are poorly understood, immune system disturbances likely underlie its development.
Sphingolipids (SLs) have been identified as important players and promising therapeutic targets to control inflammation in IBD.
Interestingly, it seems that microorganisms of the normal gut microbiota and probiotics are involved in sphingolipid function.
However, there is a great need to investigate the role of SLs as intermediates in the crosstalk between intestinal immunity and microorganisms.
This review focuses on recent investigations that describe some mechanisms involved in the regulation of cytokine profiles by SLs.
We also describe the importance of gut microbiota in providing signaling molecules that favor the communication between resident bacteria and intestinal cells.
This, in turn, modulates the immune response in the bowel and likely in other peripheral organs.
The potential of SLs and gut microbiota as targets or therapeutic agents for IBD is also discussed.
American Psychological Association (APA)
Phillips-Farfán, Bryan& Carvajal, Karla& Medina-Torres, Edgar Alejandro& Espinosa-Padilla, Sara Elva& Fabrias, Gemma& Camacho, Luz. 2016. Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111338
Modern Language Association (MLA)
Phillips-Farfán, Bryan…[et al.]. Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease. Mediators of Inflammation No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1111338
American Medical Association (AMA)
Phillips-Farfán, Bryan& Carvajal, Karla& Medina-Torres, Edgar Alejandro& Espinosa-Padilla, Sara Elva& Fabrias, Gemma& Camacho, Luz. Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease. Mediators of Inflammation. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1111338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1111338