Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats
Joint Authors
Fu, Mingyu
Tang, Jie
Hang, Jianfeng
Pan, Wenlu
Chang, Aoshuang
Li, Shun
Li, Cuixian
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Prestin is the motor protein expressed in the cochlear outer hair cells (OHCs) of mammalian inner ear.
The electromotility of OHCs driven by prestin is responsible for the cochlear amplification which is required for normal hearing in adult animals.
Postnatal expression of prestin and activity of OHCs may contribute to the maturation of hearing in rodents.
However, the temporal and spatial expression of prestin in cochlea during the development is not well characterized.
In the present study, we examined the expression and function of prestin from the OHCs in apical, middle, and basal turns of the cochleae of postnatal rats.
Prestin first appeared at postnatal day 6 (P6) for basal turn, P7 in middle turn, and P9 for apical turn of cochlea.
The expression level increased progressively over the next few days and by P14 reached the mature level for all three segments.
By comparison with the time course of the development of auditory brainstem response for different frequencies, our data reveal that prestin expression synchronized with the hearing development.
The present study suggests that the onset time of hearing may require the expression of prestin and is determined by the mature function of OHCs.
American Psychological Association (APA)
Hang, Jianfeng& Pan, Wenlu& Chang, Aoshuang& Li, Shun& Li, Cuixian& Fu, Mingyu…[et al.]. 2016. Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats. Neural Plasticity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113147
Modern Language Association (MLA)
Hang, Jianfeng…[et al.]. Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats. Neural Plasticity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113147
American Medical Association (AMA)
Hang, Jianfeng& Pan, Wenlu& Chang, Aoshuang& Li, Shun& Li, Cuixian& Fu, Mingyu…[et al.]. Synchronized Progression of Prestin Expression and Auditory Brainstem Response during Postnatal Development in Rats. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113147