Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats

Joint Authors

Chen, Shuping
Feng, Xiumei
Yan, Yaxia
Liu, Junling
Chen, Renbo
Lippe, Irmgard Th.
Litscher, Daniela
Wang, Lu
Litscher, Gerhard
Zhang, Jian-liang
Gao, Yong-hui
Gaischek, Ingrid
Wang, Jun-ying

Source

Neural Plasticity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-10-19

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Biology
Medicine

Abstract EN

To study the effects of acupuncture analgesia on the hippocampus, we observed the effects of electroacupuncture (EA) and mitogen-activated protein kinase (MEK) inhibitor on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the hippocampal area CA1 of sham or chronic constrictive injury (CCI) rats.

The animals were randomly divided into a control, a CCI, and a U0126 (MEK1/2 inhibitor) group.

In all experiments, we briefly (10-second duration) stimulated the sciatic nerve electrically and recorded the firing rates of PENs and PINs.

The results showed that in both sham and CCI rats brief sciatic nerve stimulation significantly increased the electrical activity of PENs and markedly decreased the electrical activity of PINs.

These effects were significantly greater in CCI rats compared to sham rats.

EA treatment reduced the effects of the noxious stimulus on PENs and PINs in both sham and CCI rats.

The effects of EA treatment could be inhibited by U0126 in sham-operated rats.

The results suggest that EA reduces effects of acute sciatic nerve stimulation on PENs and PINs in the CA1 region of the hippocampus of both sham and CCI rats and that the ERK (extracellular regulated kinase) signaling pathway is involved in the modulation of EA analgesia.

American Psychological Association (APA)

Wang, Jun-ying& Chen, Renbo& Chen, Shuping& Gao, Yong-hui& Zhang, Jian-liang& Feng, Xiumei…[et al.]. 2016. Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats. Neural Plasticity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113231

Modern Language Association (MLA)

Wang, Jun-ying…[et al.]. Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats. Neural Plasticity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1113231

American Medical Association (AMA)

Wang, Jun-ying& Chen, Renbo& Chen, Shuping& Gao, Yong-hui& Zhang, Jian-liang& Feng, Xiumei…[et al.]. Electroacupuncture Reduces the Effects of Acute Noxious Stimulation on the Electrical Activity of Pain-Related Neurons in the Hippocampus of Control and Neuropathic Pain Rats. Neural Plasticity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1113231

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1113231