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Comparison of Human Papillomavirus Detection in Urine and Cervical Samples Using High-Risk HPV DNA Testing in Northern Thailand
Joint Authors
Settakorn, Jongkolnee
Sukpan, Kornkanok
Siriaunkgul, Sumalee
Lekawanvijit, Suree
Katruang, Narisara
Khunamornpong, Surapan
Source
Obstetrics and Gynecology International
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-12-22
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Objective.
To evaluate the performance of high-risk human papillomavirus (HPV) DNA testing in urine samples compared to that of cervical sample testing in Northern Thailand.
Methods.
Paired urine and cervical samples were collected during the follow-up of women with a previous positive HPV test.
HPV testing was performed using the Cobas 4800 HPV Test.
Linear Array assay was used for genotyping in selected cases.
Results.
Paired urine and cervical samples were obtained from 168 women.
Of 123 paired samples with valid results, agreement in the detection of high-risk HPV DNA was present in 106 cases (86.2%), with a kappa statistic of 0.65 (substantial agreement).
Using the cervical HPV results as a reference, the sensitivity of urine HPV testing was 68.6% (24/35) and the specificity 93.2% (82/88).
For the detection of histologic high-grade squamous intraepithelial lesion or worse (HSIL+), the sensitivity of urine HPV testing was 80.0% (4/5) and the specificity 78.0% (92/118).
Conclusion.
Although urine HPV testing had a rather low sensitivity for HPV detection, its sensitivity for histologic HSIL+ detection was high.
For clinical use of urine HPV testing, standardization of specimen collection and processing techniques or application of a more sensitive test, especially in the detection of HPV52 and HPV58, is necessary.
American Psychological Association (APA)
Khunamornpong, Surapan& Settakorn, Jongkolnee& Sukpan, Kornkanok& Lekawanvijit, Suree& Katruang, Narisara& Siriaunkgul, Sumalee. 2016. Comparison of Human Papillomavirus Detection in Urine and Cervical Samples Using High-Risk HPV DNA Testing in Northern Thailand. Obstetrics and Gynecology International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113505
Modern Language Association (MLA)
Khunamornpong, Surapan…[et al.]. Comparison of Human Papillomavirus Detection in Urine and Cervical Samples Using High-Risk HPV DNA Testing in Northern Thailand. Obstetrics and Gynecology International No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1113505
American Medical Association (AMA)
Khunamornpong, Surapan& Settakorn, Jongkolnee& Sukpan, Kornkanok& Lekawanvijit, Suree& Katruang, Narisara& Siriaunkgul, Sumalee. Comparison of Human Papillomavirus Detection in Urine and Cervical Samples Using High-Risk HPV DNA Testing in Northern Thailand. Obstetrics and Gynecology International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1113505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113505