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Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle
Joint Authors
Nagahisa, Hiroshi
Mukai, Kazutaka
Ohmura, Hajime
Takahashi, Toshiyuki
Miyata, Hirofumi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-09-19
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hypoxic training is believed to increase endurance capacity in association with hypoxia inducible factor-1α (HIF-1α), a modulator of vascular endothelial growth factor-A (VEGF-A), and to influence activation of satellite cells (SCs).
However, the effect of hypoxic training on SC activation and its relation to angiogenesis has not been thoroughly investigated.
Eight Thoroughbred horses were subjected to normoxic ( F I O 2 = 21%) or hypoxic ( F I O 2 = 15%) training for 3 days/week (100% V ˙ O 2 m a x ) for 4 weeks.
Incremental exercise tests (IET) were conducted on a treadmill under normoxia and the maximal oxygen consumption ( V ˙ O 2 m a x ) and running distance were measured before and after each training session.
Muscle biopsy samples were obtained from the gluteus medius muscle at 6 scheduled times before, during, and one week after IET for immunohistochemical analysis and real-time RT-PCR analysis.
Running distance and V ˙ O 2 m a x , measured during IET, increased significantly after hypoxic training compared with normoxic training.
Capillary density and mRNA expression related to SC activation (e.g., myogenin and hepatocyte growth factor) and angiogenesis (VEGF-A) increased only after hypoxic training.
These results suggest that increases in mRNA expression after training enhance and prolong SC activation and angiogenesis and that nitric oxide plays an important role in these hypoxia-induced training effects.
American Psychological Association (APA)
Nagahisa, Hiroshi& Mukai, Kazutaka& Ohmura, Hajime& Takahashi, Toshiyuki& Miyata, Hirofumi. 2016. Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113624
Modern Language Association (MLA)
Nagahisa, Hiroshi…[et al.]. Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1113624
American Medical Association (AMA)
Nagahisa, Hiroshi& Mukai, Kazutaka& Ohmura, Hajime& Takahashi, Toshiyuki& Miyata, Hirofumi. Effect of High-Intensity Training in Normobaric Hypoxia on Thoroughbred Skeletal Muscle. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1113624
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113624