Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis
Joint Authors
Monteiro, Marta Chagas
Torres, Yohandra Reyes
Machado, Christiane Schineider
Lira, Tatiana Onofre de
Ferreira, Antonio Gilberto
Fontes-Júnior, Enéas Andrade
Maia, Cristiane Socorro Ferraz
Fernandes, Luanna Melo Pereira
da Silveira, Cinthia Cristina Sousa de Menezes
Silva, Mallone Lopes
Luz, Diandra Araújo
Gomes, Antônio Rafael Quadros
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-10-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Propolis is a resin produced by bees from raw material collected from plants, salivary secretions, and beeswax.
New therapeutic properties for the Central Nervous System have emerged.
We explored the neurobehavioral and antioxidant effects of an ethanolic extract of yellow propolis (EEYP) rich in triterpenoids, primarily lupeol and β-amyrin.
Male Wistar rats, 3 months old, were intraperitoneally treated with Tween 5% (control), EEYP (1, 3, 10, and 30 mg/kg), or diazepam, fluoxetine, and caffeine (positive controls) 30 min before the assays.
Animals were submitted to open field, elevated plus maze, forced swimming, and inhibitory avoidance tests.
After behavioral tasks, blood samples were collected through intracardiac pathway, to evaluate the oxidative balance.
The results obtained in the open field and in the elevated plus maze assay showed spontaneous locomotion preserved and anxiolytic-like activity.
In the forced swimming test, EEYP demonstrated antidepressant-like activity.
In the inhibitory avoidance test, EEYP showed mnemonic activity at 30 mg/kg.
In the evaluation of oxidative biochemistry, the extract reduced the production of nitric oxide and malondialdehyde without changing level of total antioxidant, catalase, and superoxide dismutase, induced by behavioral stress.
Our results highlight that EEYP emerges as a promising anxiolytic, antidepressant, mnemonic, and antioxidant natural product.
American Psychological Association (APA)
da Silveira, Cinthia Cristina Sousa de Menezes& Fernandes, Luanna Melo Pereira& Silva, Mallone Lopes& Luz, Diandra Araújo& Gomes, Antônio Rafael Quadros& Monteiro, Marta Chagas…[et al.]. 2016. Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113752
Modern Language Association (MLA)
da Silveira, Cinthia Cristina Sousa de Menezes…[et al.]. Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1113752
American Medical Association (AMA)
da Silveira, Cinthia Cristina Sousa de Menezes& Fernandes, Luanna Melo Pereira& Silva, Mallone Lopes& Luz, Diandra Araújo& Gomes, Antônio Rafael Quadros& Monteiro, Marta Chagas…[et al.]. Neurobehavioral and Antioxidant Effects of Ethanolic Extract of Yellow Propolis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1113752
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113752