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Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches
Joint Authors
Balmus, Ioana Miruna
Ciobica, Alin
Antioch, Iulia
Dobrin, Romeo
Timofte, Daniel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-25, 25 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-01
Country of Publication
Egypt
No. of Pages
25
Main Subjects
Abstract EN
The correlation between the affective disorders and the almost ubiquitous pathological oxidative stress can be described in a multifactorial way, as an important mechanism of central nervous system impairment.
Whether the obvious changes which occur in oxidative balance of the affective disorders are a part of the constitutive mechanism or a collateral effect yet remains as an interesting question.
However it is now clear that oxidative stress is a component of these disorders, being characterized by different aspects in a disease-dependent manner.
Still, there are a lot of controversies regarding the relevance of the oxidative stress status in most of the affective disorders and despite the fact that most of the studies are showing that the affective disorders development can be correlated to increased oxidative levels, there are various studies stating that oxidative stress is not linked with the mood changing tendencies.
Thus, in this minireview we decided to describe the way in which oxidative stress is involved in the affective disorders development, by focusing on the main oxidative stress markers that could be used mechanistically and therapeutically in these deficiencies, the genetic perspectives, some antioxidant approaches, and the relevance of some animal models studies in this context.
American Psychological Association (APA)
Balmus, Ioana Miruna& Ciobica, Alin& Antioch, Iulia& Dobrin, Romeo& Timofte, Daniel. 2016. Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1113885
Modern Language Association (MLA)
Balmus, Ioana Miruna…[et al.]. Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-25.
https://search.emarefa.net/detail/BIM-1113885
American Medical Association (AMA)
Balmus, Ioana Miruna& Ciobica, Alin& Antioch, Iulia& Dobrin, Romeo& Timofte, Daniel. Oxidative Stress Implications in the Affective Disorders: Main Biomarkers, Animal Models Relevance, Genetic Perspectives, and Antioxidant Approaches. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-25.
https://search.emarefa.net/detail/BIM-1113885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1113885