Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats
Joint Authors
Pokkunuri, Indira
Ali, Quaisar
Asghar, Mohammad
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-07-27
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We examined the effects and mechanism of grape powder- (GP-) mediated improvement, if any, on aging kidney function.
Adult (3-month) and aged (21-month) Fischer 344 rats were treated without (controls) and with GP (1.5% in drinking water) and kidney parameters were measured.
Control aged rats showed higher levels of proteinuria and urinary kidney injury molecule-1 (KIM-1), which decreased with GP treatment in these rats.
Renal protein carbonyls (protein oxidation) and gp 91phox-NADPH oxidase levels were high in control aged rats, suggesting oxidative stress burden in these rats.
GP treatment in aged rats restored these parameters to the levels of adult rats.
Moreover, glomerular filtration rate and sodium excretion were low in control aged rats suggesting compromised kidney function, which improved with GP treatment in aged rats.
Interestingly, low renal mitochondrial respiration and ATP levels in control aged rats were associated with reduced levels of mitochondrial biogenesis marker MtTFA.
Also, Nrf2 proteins levels were reduced in control aged rats.
GP treatment increased levels of MtTFA and Nrf2 in aged rats.
These results suggest that GP by potentially regulating Nrf2 improves aging mitochondrial and kidney functions.
American Psychological Association (APA)
Pokkunuri, Indira& Ali, Quaisar& Asghar, Mohammad. 2016. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
Modern Language Association (MLA)
Pokkunuri, Indira…[et al.]. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
American Medical Association (AMA)
Pokkunuri, Indira& Ali, Quaisar& Asghar, Mohammad. Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114085
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114085