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Antioxidant Effects of Sheep Whey Protein on Endothelial Cells
Joint Authors
Kouretas, Dimitrios
Kafantaris, Ioannis
Kerasioti, Efthalia
Georgatzi, Vasiliki
Bregou, Erinda
Priftis, Alexandros
Stagos, Dimitrios
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Excessive production of reactive oxygen species (ROS) may cause endothelial dysfunction and consequently vascular disease.
In the present study, the possible protective effects of sheep whey protein (SWP) from tert-butyl hydroperoxide- (tBHP-) induced oxidative stress in endothelial cells (EA.hy926) were assessed using oxidative stress biomarkers.
These oxidative stress biomarkers were glutathione (GSH) and ROS levels determined by flow cytometry.
Moreover, thiobarbituric acid-reactive substances (TBARS), protein carbonyls (CARB), and oxidized glutathione (GSSG) were determined spectrophotometrically.
The results showed that SWP at 0.78, 1.56, 3.12, and 6.24 mg of protein mL−1 increased GSH up to 141%, while it decreased GSSG to 46.7%, ROS to 58.5%, TBARS to 52.5%, and CARB to 49.0%.
In conclusion, the present study demonstrated for the first time that SWP protected endothelial cells from oxidative stress.
Thus, SWP may be used for developing food supplements or biofunctional foods to attenuate vascular disturbances associated with oxidative stress.
American Psychological Association (APA)
Kerasioti, Efthalia& Stagos, Dimitrios& Georgatzi, Vasiliki& Bregou, Erinda& Priftis, Alexandros& Kafantaris, Ioannis…[et al.]. 2016. Antioxidant Effects of Sheep Whey Protein on Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114125
Modern Language Association (MLA)
Kerasioti, Efthalia…[et al.]. Antioxidant Effects of Sheep Whey Protein on Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114125
American Medical Association (AMA)
Kerasioti, Efthalia& Stagos, Dimitrios& Georgatzi, Vasiliki& Bregou, Erinda& Priftis, Alexandros& Kafantaris, Ioannis…[et al.]. Antioxidant Effects of Sheep Whey Protein on Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114125