Metabolic Syndrome Augments the Risk of Early Neurological Deterioration in Acute Ischemic Stroke Patients Independent of Inflammatory Mediators: A Hospital-Based Prospective Study

Joint Authors

Xie, Yi
Zhang, Xiaohao
Sun, Zhiguang
Ding, Caixia
Tang, Yinyan
Jiang, Xuemei
Li, Chuanyou
Zhang, Lankun
Hu, Dan
Li, Tingting
Xu, Gelin
Sheng, Lei

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2016-03-29

Country of Publication

Egypt

No. of Pages

6

Main Subjects

Biology

Abstract EN

Background and Aims.

Metabolic syndrome (MetS) has been associated with occurrence and prognosis of ischemic stroke.

This study aimed to evaluate whether an association exists between MetS and early neurological deterioration (END) following acute ischemic stroke and the possible role inflammatory biomarkers play.

Methods and Results.

We conducted a prospective cohort investigation that involved 208 stroke patients within 48 hours from symptom onset.

MetS was determined by the modified National Cholesterol Education Program/Adult Treatment Panel III criteria.

END was defined as an increase of ⩾1 point in motor power or ⩾2 points in the total National Institutes of Health Stroke Scale (NIHSS) score within 7 days.

Univariate logistic regression analysis showed that patients with MetS had a 125% increased risk of END (OR 2.25; 95% CI 1.71–4.86, P=0.005).

After adjustment for fibrinogen and high-sensitivity C-reactive protein, MetS remained significantly correlated to END (OR 2.20; 95% CI 1.10–4.04, P=0.026) with a 77% elevated risk per additional MetS trait (OR 1.77; 95% CI 1.23–2.58, P=0.002).

Conclusions.

This study demonstrated that MetS may be a potential predictor for END after ischemic stroke, which was independent of raised inflammatory mediators.

American Psychological Association (APA)

Zhang, Xiaohao& Sun, Zhiguang& Ding, Caixia& Tang, Yinyan& Jiang, Xuemei& Xie, Yi…[et al.]. 2016. Metabolic Syndrome Augments the Risk of Early Neurological Deterioration in Acute Ischemic Stroke Patients Independent of Inflammatory Mediators: A Hospital-Based Prospective Study. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114339

Modern Language Association (MLA)

Zhang, Xiaohao…[et al.]. Metabolic Syndrome Augments the Risk of Early Neurological Deterioration in Acute Ischemic Stroke Patients Independent of Inflammatory Mediators: A Hospital-Based Prospective Study. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114339

American Medical Association (AMA)

Zhang, Xiaohao& Sun, Zhiguang& Ding, Caixia& Tang, Yinyan& Jiang, Xuemei& Xie, Yi…[et al.]. Metabolic Syndrome Augments the Risk of Early Neurological Deterioration in Acute Ischemic Stroke Patients Independent of Inflammatory Mediators: A Hospital-Based Prospective Study. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114339

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1114339