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Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review
Joint Authors
Jamurtas, Athanasios Z.
Poulianiti, Konstantina P.
Kaltsatou, Antonia
Mitrou, Georgia I.
Koutedakis, Yiannis
Maridaki, Maria
Stefanidis, Ioannis
Sakkas, Giorgos K.
Karatzaferi, Christina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-08-03
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Patients with chronic kidney disease (CKD) experience imbalance between oxygen reactive species (ROS) production and antioxidant defenses leading to cell and tissue damage.
However, it remains unclear at which stage of renal insufficiency the redox imbalance becomes more profound.
The aim of this systematic review was to provide an update on recent advances in our understanding of how the redox status changes in the progression of renal disease from predialysis stages 1 to 4 to end stage 5 and whether the various treatments and dialysis modalities influence the redox balance.
A systematic review was conducted searching PubMed and Scopus by using the Cochrane and PRISMA guidelines.
In total, thirty-nine studies met the inclusion criteria and were reviewed.
Even from an early stage, imbalance in redox status is evident and as the kidney function worsens it becomes more profound.
Hemodialysis therapy per se seems to negatively influence the redox status by the elevation of lipid peroxidation markers, protein carbonylation, and impairing erythrocyte antioxidant defense.
However, other dialysis modalities do not so far appear to confer advantages.
Supplementation with antioxidants might assist and should be considered as an early intervention to halt premature atherogenesis development at an early stage of CKD.
American Psychological Association (APA)
Poulianiti, Konstantina P.& Kaltsatou, Antonia& Mitrou, Georgia I.& Jamurtas, Athanasios Z.& Koutedakis, Yiannis& Maridaki, Maria…[et al.]. 2016. Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114403
Modern Language Association (MLA)
Poulianiti, Konstantina P.…[et al.]. Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114403
American Medical Association (AMA)
Poulianiti, Konstantina P.& Kaltsatou, Antonia& Mitrou, Georgia I.& Jamurtas, Athanasios Z.& Koutedakis, Yiannis& Maridaki, Maria…[et al.]. Systemic Redox Imbalance in Chronic Kidney Disease: A Systematic Review. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114403
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114403