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Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats
Joint Authors
Brambila, Eduardo
Guevara, J.
Treviño, Samuel
Díaz, Alfonso
Muñoz-Arenas, Guadalupe
Espinosa, Blanca
Moreno-Rodríguez, Albino
Lopez-Lopez, Gustavo
Peña-Rosas, Ulises
Venegas, Berenice
Handal-Silva, Anabella
Morán-Perales, José Luis
Flores, Gonzalo
Aguilar-Alonso, Patricia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Energy drinks (EDs) are often consumed in combination with alcohol because they reduce the depressant effects of alcohol.
However, different researches suggest that chronic use of these psychoactive substances in combination with alcohol can trigger an oxidative and inflammatory response.
These processes are regulated by both a reactive astrogliosis and an increase of proinflammatory cytokines such as IL-1β, TNF-α, and iNOS, causing cell death (apoptosis) at the central and peripheral nervous systems.
Currently, mechanisms of toxicity caused by mixing alcohol and ED in the brain are not well known.
In this study, we evaluated the effect of chronic alcohol consumption in combination with ED on inflammatory response and oxidative stress in the temporal cortex (TCx) and hippocampus (Hp) of adult rats (90 days old).
Our results demonstrated that consuming a mixture of alcohol and ED for 60 days induced an increase in reactive gliosis, IL-1β, TNF-α, iNOS, reactive oxygen species, lipid peroxidation, and nitric oxide, in the TCx and Hp.
We also found immunoreactivity to caspase-3 and a decrease of synaptophysin in the same brain regions.
The results suggested that chronic consumption of alcohol in combination with ED causes an inflammatory response and oxidative stress, which induced cell death via apoptosis in the TCx and Hp of the adult rats.
American Psychological Association (APA)
Díaz, Alfonso& Treviño, Samuel& Guevara, J.& Muñoz-Arenas, Guadalupe& Brambila, Eduardo& Espinosa, Blanca…[et al.]. 2016. Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114457
Modern Language Association (MLA)
Díaz, Alfonso…[et al.]. Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114457
American Medical Association (AMA)
Díaz, Alfonso& Treviño, Samuel& Guevara, J.& Muñoz-Arenas, Guadalupe& Brambila, Eduardo& Espinosa, Blanca…[et al.]. Energy Drink Administration in Combination with Alcohol Causes an Inflammatory Response and Oxidative Stress in the Hippocampus and Temporal Cortex of Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114457
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114457