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Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis
Joint Authors
Yılmaz, Zülfükar
Kara, Ali Veysel
Cellad, Esma Gulsum
Gul, Mesut
Ketani, Muzaffer Aydin
Yilmaz, Mehmet Emin
Bahadir, Mehmet Veysi
Yıldırım, Yaşar
Kadiroğlu, Ali Kemal
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Our aim was to evaluate effect of etanercept on oxidative stress parameters in rats with experimental peritonitis and investigate the availability of etanercept usage in the treatment of peritonitis in the future.
Twenty-eight rats were divided into four groups as control (group 1), peritonitis (group 2), peritonitis + cefazolin sodium (group 3), and peritonitis + cefazolin sodium + etanercept (group 4).
Peritoneal tissue and blood samples were taken from all of the rats for histopathological and biochemical examination.
The oxidative stress parameters were examined in blood and tissue samples.
It was observed that rats with peritonitis benefit from cefazolin sodium treatment.
Evaluating the effectiveness of etanercept was our main objective for this study.
In this perspective, we compared group 3 and group 4 and found statistically significant decreases in oxidative parameters and statistically significant increases in antioxidants in serum and tissue samples in group 4.
It is observed that there was a significant contribution of etanercept on biochemical and also histopathological results.
As a result, the TNF-α inhibitor, etanercept, in addition to antibiotics given in the early treatment of peritonitis results in more significant improvement of histopathological and oxidative parameters as compared to antibiotics alone.
American Psychological Association (APA)
Yıldırım, Yaşar& Cellad, Esma Gulsum& Kara, Ali Veysel& Yılmaz, Zülfükar& Kadiroğlu, Ali Kemal& Bahadir, Mehmet Veysi…[et al.]. 2016. Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114765
Modern Language Association (MLA)
Yıldırım, Yaşar…[et al.]. Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1114765
American Medical Association (AMA)
Yıldırım, Yaşar& Cellad, Esma Gulsum& Kara, Ali Veysel& Yılmaz, Zülfükar& Kadiroğlu, Ali Kemal& Bahadir, Mehmet Veysi…[et al.]. Effect of Intraperitoneal Etanercept on Oxidative Stress in Rats with Peritonitis. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1114765
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114765