Pelvic Radiotherapy versus Radical Prostatectomy with Limited Lymph Node Sampling for High-Grade Prostate Adenocarcinoma
Joint Authors
Nix, Jeffrey W.
Baker, Christopher B.
McDonald, Andrew M.
Yang, Eddy S.
Jacob, Rojymon
Rais-Bahrami, Soroush
Fiveash, John B.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-03-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Purpose.
To compare oncologic outcomes for patients with Gleason score (GS) ≥ 8 prostate adenocarcinoma treated with radical prostatectomy (RP) versus external beam radiotherapy combined with androgen deprivation (RT + ADT).
Methods.
Between 2001 and 2014, 121 patients with GS ≥ 8 were treated at our institution via RT + ADT ( n = 71 ) or RP ( n = 50 ) with ≥ 1 year of biochemical follow-up.
Endpoints included biochemical failure (BF), distant metastasis, and initiation of salvage ADT.
Results.
The RT + ADT group was older, had higher biopsy GS, and had greater risk of lymph node involvement.
All other pretreatment characteristics were similar between groups.
Mean number of lymph nodes (LNs) sampled for patients undergoing RP was 8.2 (±6.18).
Mean biochemical follow-up for all patients was 61 months.
Five-year estimates of BF for the RT + ADT and RP groups were 7.2% versus 42.3%, ( p < 0.001 ).
The RT + ADT group also had lower rates of distant metastasis (2% versus 7.8%) and salvage ADT (8% versus 33.8%).
Conclusion.
In this analysis, RT + ADT was associated with improved biochemical and metastatic control when compared to RP with limited LN sampling.
How RT + ADT compares with more aggressive lymphadenectomy, as is currently our institutional standard, remains an important unanswered question.
American Psychological Association (APA)
Baker, Christopher B.& McDonald, Andrew M.& Yang, Eddy S.& Jacob, Rojymon& Rais-Bahrami, Soroush& Nix, Jeffrey W.…[et al.]. 2016. Pelvic Radiotherapy versus Radical Prostatectomy with Limited Lymph Node Sampling for High-Grade Prostate Adenocarcinoma. Prostate Cancer،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114889
Modern Language Association (MLA)
Baker, Christopher B.…[et al.]. Pelvic Radiotherapy versus Radical Prostatectomy with Limited Lymph Node Sampling for High-Grade Prostate Adenocarcinoma. Prostate Cancer No. 2016 (2016), pp.1-8.
https://search.emarefa.net/detail/BIM-1114889
American Medical Association (AMA)
Baker, Christopher B.& McDonald, Andrew M.& Yang, Eddy S.& Jacob, Rojymon& Rais-Bahrami, Soroush& Nix, Jeffrey W.…[et al.]. Pelvic Radiotherapy versus Radical Prostatectomy with Limited Lymph Node Sampling for High-Grade Prostate Adenocarcinoma. Prostate Cancer. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1114889
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114889