Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite
Joint Authors
Schirmer, Henrik
Sibille, Kimberly T.
Steingrímsdóttir, Ólöf A.
Fillingim, Roger B.
Stubhaug, Audun
Chen, Huaihou
McEwen, Bruce S.
Nielsen, Christopher S.
Source
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-06-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease and cancer.
Investigating related risk factor measures may elucidate the biological burden of chronic pain.
Objectives.
We hypothesized that chronic pain severity would be positively associated with the risk factor composite.
Methods.
Data from 12,982 participants in the 6th Tromsø study were analyzed.
Questionnaires included demographics, health behaviors, medical comorbidities, and chronic pain symptoms.
The risk factor composite was comprised of body mass index, fibrinogen, C-reactive protein, and triglycerides.
Chronic pain severity was characterized by frequency, intensity, time/duration, and total number of pain sites.
Results.
Individuals with chronic pain had a greater risk factor composite than individuals without chronic pain controlling for covariates and after excluding inflammation-related health conditions ( p < 0.001 ).
A significant “dose-response” relationship was demonstrated with pain severity ( p < 0.001 ).
In individuals with chronic pain, the risk factor composite varied by health behavior, exercise, lower levels and smoking, and higher levels.
Discussion.
The risk factor composite was higher in individuals with chronic pain, greater with increasing pain severity, and influenced by health behaviors.
Conclusions.
Identification of a biological composite sensitive to pain severity and adaptive/maladaptive behaviors would have significant clinical and research utility.
American Psychological Association (APA)
Sibille, Kimberly T.& Steingrímsdóttir, Ólöf A.& Fillingim, Roger B.& Stubhaug, Audun& Schirmer, Henrik& Chen, Huaihou…[et al.]. 2016. Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Research and Management،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115498
Modern Language Association (MLA)
Sibille, Kimberly T.…[et al.]. Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Research and Management No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1115498
American Medical Association (AMA)
Sibille, Kimberly T.& Steingrímsdóttir, Ólöf A.& Fillingim, Roger B.& Stubhaug, Audun& Schirmer, Henrik& Chen, Huaihou…[et al.]. Investigating the Burden of Chronic Pain: An Inflammatory and Metabolic Composite. Pain Research and Management. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115498
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1115498