Multiple Functions of MSCA-1TNAP in Adult Mesenchymal ProgenitorStromal Cells

Joint Authors

Estève, David
Galitzky, Jean
Bouloumié, Anne
Fonta, Caroline
Buchet, René
Magne, David

Source

Stem Cells International

Issue

Vol. 2016, Issue 2016 (31 Dec. 2015), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2015-12-29

Country of Publication

Egypt

No. of Pages

8

Abstract EN

Our knowledge about mesenchymal stem cells has considerably grown in the last years.

Since the proof of concept of the existence of such cells in the 70s by Friedenstein et al., a growing mass of reports were conducted for a better definition of these cells and for the reevaluation from the term “mesenchymal stem cells” to the term “mesenchymal stromal cells (MSCs).” Being more than a semantic shift, concepts behind this new terminology reveal the complexity and the heterogeneity of the cells grouped in MSC family especially as these cells are present in nearly all adult tissues.

Recently, mesenchymal stromal cell antigen-1 (MSCA-1)/tissue nonspecific alkaline phosphatase (TNAP) was described as a new cell surface marker of MSCs from different tissues.

The alkaline phosphatase activity of this protein could be involved in wide range of MSC features described below from cell differentiation to immunomodulatory properties, as well as occurrence of pathologies.

The present review aims to decipher and summarize the role of TNAP in progenitor cells from different tissues focusing preferentially on brain, bone marrow, and adipose tissue.

American Psychological Association (APA)

Estève, David& Galitzky, Jean& Bouloumié, Anne& Fonta, Caroline& Buchet, René& Magne, David. 2015. Multiple Functions of MSCA-1TNAP in Adult Mesenchymal ProgenitorStromal Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116143

Modern Language Association (MLA)

Estève, David…[et al.]. Multiple Functions of MSCA-1TNAP in Adult Mesenchymal ProgenitorStromal Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116143

American Medical Association (AMA)

Estève, David& Galitzky, Jean& Bouloumié, Anne& Fonta, Caroline& Buchet, René& Magne, David. Multiple Functions of MSCA-1TNAP in Adult Mesenchymal ProgenitorStromal Cells. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116143

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1116143